Anti-SM and Anti-U1-RNP Lupus Antibody Fine Specificities

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 1989 May 1

PMID 2475520

Citations 4

Authors

A M Francoeur

Affiliations

Soon will be listed here.

Abstract

Evidence for the presence of multiple shared epitopes on the target cellular antigens was found when 290 anti-Sm and anti-U1-RNP lupus sera were analyzed by immunoblotting. Forty-eight different immunoblot patterns were observed with the sera. Studies with selected antigen-affinity-purified antibodies confirmed the presence of multiple shared epitopes, in agreement with findings obtained with monoclonal antibodies. The results have implications for the design of effective diagnostics and for the use of these antibodies as molecular probes.

Citing Articles

Distinctive immune response patterns of human and murine autoimmune sera to U1 small nuclear ribonucleoprotein C protein.

Satoh M, Langdon J, Hamilton K, Richards H, Panka D, Eisenberg R J Clin Invest. 1996; 97(11):2619-26.

PMID: 8647956 PMC: 507349. DOI: 10.1172/JCI118711.

Analysis of autoantibody specificities in selected systemic lupus erythematosus (SLE) sera.

Francoeur A J Clin Immunol. 1989; 9(3):248-55.

PMID: 2504762 DOI: 10.1007/BF00916821.

Multiple overlapping homologies between two rheumatoid antigens and immunosuppressive viruses.

Douvas A, Sobelman S Proc Natl Acad Sci U S A. 1991; 88(14):6328-32.

PMID: 1712488 PMC: 52076. DOI: 10.1073/pnas.88.14.6328.

B-cell epitopes of Sm autoantigens.

Rokeach L, Hoch S Mol Biol Rep. 1992; 16(3):165-74.

PMID: 1380640 DOI: 10.1007/BF00464704.

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