A Case of IgG4-related Disease with Bronchial Asthma and Chronic Rhinosinusitis in Korea

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2014 Apr 23

PMID 24753711

Citations 5

Authors

Young-Soo Lee

Hyo-Jeong Cho

Hye-Soo Yoo

Yoo-Sub Shin

Hae-Sim Park

Affiliations

Soon will be listed here.

Abstract

IgG4-related disease (IgG4-RD) is characterized by a systemic involvement of tumor-like lesions with IgG4-positive plasmacytes. We experienced a case of IgG4-RD developed in a patient with bronchial asthma (BA) and chronic rhinosinusitis (CRS). A 55-yr-old female patient with BA and CRS complained of both eyes and neck swelling as well as a recurrent upper respiratory infection in recent 1 yr. The serum levels of IgG4, creatinine, and pancreatic enzymes were elevated. A biopsy of the submandibular gland showed an abundant infiltration of IgG4-positive plasmacytes. Her symptoms remarkably improved after the treatment of a systemic steroid that has been maintained without recurrence. We report a rare case of IgG4-RD developed in a patient with BA and CRS.

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