MicroRNA-194 Inhibits the Epithelial-mesenchymal Transition in Gastric Cancer Cells by Targeting FoxM1

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2014 Apr 22

PMID 24748184

Citations 26

Authors

Zhenjun Li

Xiaojiang Ying

Hongliang Chen

Pingjiang Ye

Yi Shen

Weihuo Pan

Lihua Zhang

Affiliations

Soon will be listed here.

Abstract

Aim: We hypothesized that miR-194 may control Forkhead box protein M1 (FoxM1) expression in gastric cancer cells and therefore may have therapeutic potential in gastric cancer.

Methods: The expression level of miR-194 was examined using real-time PCR in human gastric cancer and noncancerous gastric tissues, gastric cancer cell and normal gastric mucosal epithelial cell. We examined whether the miR-194 regulates cell migration and invasion, and the epithelial-mesenchymal transition Phenotype by inhibiting FoxM1 in gastric cancer cells.

Results: The expression of miR-194 was significantly lower in gastric cancer compared with non-cancerous gastric tissues and cells. Exogenous expression of miR-194 inhibited cell migration, invasion, and the epithelial-mesenchymal transition phenotype in gastric cancer cells. Moreover, we discovered a novel post-transcriptional regulatory mechanism of FoxM1 expression that is mediated by miR-194.

Conclusion: Our study clearly demonstrates that miR-194 inhibits the acquisition of the EMT phenotype in gastric cancer cells by downregulating FoxM1, thereby inhibiting cell migration and invasion during cancer progression.

Citing Articles

Down-Regulation of miR-194-5p for Predicting Metastasis in Breast Cancer Cells.

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KLF5 activates lncRNA DANCR and inhibits cancer cell autophagy accelerating gastric cancer progression.

Cheng Z, Liu G, Huang C, Zhao X NPJ Genom Med. 2021; 6(1):75.

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MiR-194-5p enhances the sensitivity of nonsmall-cell lung cancer to doxorubicin through targeted inhibition of hypoxia-inducible factor-1.

Xia M, Sheng L, Qu W, Xue X, Chen H, Zheng G World J Surg Oncol. 2021; 19(1):174.

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Dysregulation of exosomal miR-192 and miR-194 expression in lung adenocarcinoma patients.

Wang T, Li W, Li H, Li W Saudi J Biol Sci. 2021; 28(3):1561-1568.

PMID: 33732041 PMC: 7938118. DOI: 10.1016/j.sjbs.2021.01.013.

miRNA-194 predicts favorable prognosis in gastric cancer and inhibits gastric cancer cell growth by targeting CCND1.

Wang J, Zhang M, Hu X, She J, Sun R, Qin S FEBS Open Bio. 2021; 11(7):1814-1826.

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