Opportunities for Merging Chemical and Biological Synthesis

Overview

Journal Curr Opin Biotechnol

Publisher Elsevier

Specialty Biotechnology

Date 2014 Apr 22

PMID 24747284

Citations 24

Authors

Stephen Wallace

Emily P Balskus

Affiliations

Soon will be listed here.

Abstract

Organic chemists and metabolic engineers use largely orthogonal technologies to access small molecules like pharmaceuticals and commodity chemicals. As the use of biological catalysts and engineered organisms for chemical production grows, it is becoming increasingly evident that future efforts for chemical manufacture will benefit from the integration and unified expansion of these two fields. This review will discuss approaches that combine chemical and biological synthesis for small molecule production. We highlight recent advances in combining enzymatic and non-enzymatic catalysis in vitro, discuss the application of design principles from organic chemistry for engineering non-biological reactivity into enzymes, and describe the development of biocompatible chemistry that can be interfaced with microbial metabolism.

Citing Articles

Concatenating Microbial, Enzymatic, and Organometallic Catalysis for Integrated Conversion of Renewable Carbon Sources.

Klos N, Osterthun O, Mengers H, Lanzerath P, Graf von Westarp W, Lim G JACS Au. 2024; 4(12):4546-4570.

PMID: 39735920 PMC: 11672146. DOI: 10.1021/jacsau.4c00511.

Biocompatible α-Methylenation of Metabolic Butyraldehyde in Living Bacteria.

Dennis J, Johnson N, Thorpe T, Wallace S Angew Chem Int Ed Engl. 2023; 62(38):e202306347.

PMID: 37477977 PMC: 10952924. DOI: 10.1002/anie.202306347.

Complementarity of solution and solid state mechanochemical reaction conditions demonstrated by 1,2-debromination of tricyclic imides.

Strbac P, Margetic D Beilstein J Org Chem. 2022; 18:746-753.

PMID: 35821693 PMC: 9235900. DOI: 10.3762/bjoc.18.75.

Tyramine Derivatives Catalyze the Aldol Dimerization of Butyraldehyde in the Presence of Escherichia coli.

Dennis J, Sadler J, Wallace S Chembiochem. 2022; 23(17):e202200238.

PMID: 35687270 PMC: 9540883. DOI: 10.1002/cbic.202200238.

Interfacing non-enzymatic catalysis with living microorganisms.

Sadler J, Dennis J, Johnson N, Wallace S RSC Chem Biol. 2021; 2(4):1073-1083.

PMID: 34458824 PMC: 8341791. DOI: 10.1039/d1cb00072a.

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