Torque Teno Virus and Hepatitis C Virus Co-infection in Iranian Pediatric Thalassemia Patients

Overview

Journal Turk J Haematol

Specialty Hematology

Date 2014 Apr 19

PMID 24744647

Citations 4

Authors

Samin Alavi

Ali Kord Valeshabad

Zohreh Sharifi

Kazem Nourbakhsh

Mohammad Taghi Arzanian

Masoumeh Navidinia

Siamak Mehdizadeh Seraj

Affiliations

Soon will be listed here.

Abstract

Objective: Torque teno virus (TTV) infects patients at risk for parenteral exposure and chronic blood transfusion, such as those with β-thalassemic. This study aimed to assess the prevalence of TTV infection and co-infection of TTV and hepatitis C virus (HCV) in pediatric thalassemia patients receiving chronic blood transfusion.

Material And Methods: The study included 90 pediatric thalassemia patients receiving chronic blood transfusion that presented to the Mofid Children's Hospital, Tehran, Iran. The control group included 90 healthy volunteer children. Serum TTV DNA detection via semi-nested PCR and HCV Ab were performed in all the participants. Demographic characteristics and clinical data were collected from each participant for statistical analysis.

Results: In all, 64.4% of the patients had TTV infection, versus 24.4% of the controls (P < 0.01). The thalassemia patients had a greater probability of having TTV and HCV infections than the controls, with a common OR of 5.60 (95% CI: 2.94-10.69) and 2.15 (95% CI: 1.83-2.50), respectively. In total, 17.2% (10/58) of the patients that were TTV positive were also HCV positive, whereas 6.3% (2/32) of the TTV-negative patients were anti-HCV antibody (Ab) positive (P = 0.14).

Conclusion: The prevalence of TTV and HCV infection was higher in the Iranian thalassemia patients on chronic transfusion therapy than in the controls. The high prevalence of TTV in pediatric thalassemia patients on chromic transfusion therapy may indicate the superiority of the parenteral route compared to other routs of TTV transmission.

Citing Articles

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The epidemiology of hepatitis C virus in Iran: Systematic review and meta-analyses.

Mahmud S, Akbarzadeh V, Abu-Raddad L Sci Rep. 2018; 8(1):150.

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