Type 2 Diabetes, PUFAs, and Vitamin D: Their Relation to Inflammation

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2014 Apr 18

PMID 24741627

Citations 20

Authors

Ana L Guadarrama-Lopez

Roxana Valdes-Ramos

Beatriz E Martinez-Carrillo

Affiliations

Soon will be listed here.

Abstract

Chronic diseases have become one of the most important public health problems, due to their high costs for treatment and prevention. Until now, researchers have considered that the etiology of Type 2 diabetes mellitus (T2DM) is multifactorial. Recently, the study of the innate immune system has offered an explanation model of the pathogenesis of T2DM. On the other hand, there is evidence about the beneficial effect of polyunsaturated fatty acids (PUFA) n-3 and n-6 in patients with chronic inflammatory diseases including diabetes. Furthermore, high vitamin D plasmatic concentrations have been associated with the best performance of pancreatic β cells and the improving of this disease. In conclusion, certain fatty acids in the adequate proportion as well as 25-hydroxivitamin D can modulate the inflammatory response in diabetic people, modifying the evolution of this disease.

Citing Articles

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Maternal Supplementation with Cow's Milk Naturally Enriched with PUFA Alters the Metabolism of Sows and the Fatty Acid Profile of the Offspring.

Garcia Reis L, Silva T, Ravagnani G, Martinez C, Salles M, Furugen Cesar Andrade A Nutrients. 2021; 13(6).

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