Gender Differences of B Cell Signature in Healthy Subjects Underlie Disparities in Incidence and Course of SLE Related to Estrogen

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2014 Apr 18

PMID 24741625

Citations 42

Authors

Hongye Fan

Guanjun Dong

Guangfeng Zhao

Fei Liu

Genghong Yao

Yichao Zhu

Yayi Hou

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to investigate mechanism of the gender differences of B cells. The results showed that 358 differential gene expressions (DEGs) were displayed between healthy females and males. Compared with male, 226 and 132 genes were found to be up- and downregulated in the female. 116 genes displayed possible correlation with estrogen. Moreover, the upregulated DEGs (Cav1, CD200R1, TNFRSF17, and CXCR3) and downregulated DEGs (EIF1AY and DDX3Y) in healthy female may be involved in gender predominance of some immune diseases. Furthermore, signaling pathway analysis for estrogen-relevant DEGs showed that only 26 genes were downregulated in SLE female versus SLE male, of which expressions of 8 genes had significant difference between SLE females and SLE males but are having nonsignificant difference between healthy females and healthy males. Except for the 5 Y-chromosome-related genes or varients, only 3 DEGs (LTF, CAMP, and DEFA4) were selected and qRT-PCR confirmed that the expressions of LTF and CAMP decreased significantly in B cells from female SLE patients. These data indicated that the gender differences were existent in global gene expression of B cells and the difference may be related to estrogen.

Citing Articles

A multi-organ map of the human immune system across age, sex and ethnicity.

Mangiola S, Milton M, Ranathunga N, Li-Wai-Suen C, Odainic A, Yang E bioRxiv. 2024; .

PMID: 38746418 PMC: 11092463. DOI: 10.1101/2023.06.08.542671.

[Sex-specific differences of special tumor diseases].

Lehnen N, Hallek M Inn Med (Heidelb). 2023; 64(8):717-726.

PMID: 37458764 PMC: 10366284. DOI: 10.1007/s00108-023-01551-9.

Revealing common differential mRNAs, signaling pathways, and immune cells in blood, glomeruli, and tubulointerstitium of lupus nephritis patients based on transcriptomic data.

Zhao H, Zheng D Ren Fail. 2023; 45(1):2215344.

PMID: 37334926 PMC: 10281411. DOI: 10.1080/0886022X.2023.2215344.

Desensitization and belatacept-based maintenance therapy in pregnancy-sensitized monkeys receiving a kidney transplant.

Manook M, Olaso D, Anwar I, Yoon J, DeLaura I, Bae Y Sci Adv. 2023; 9(20):eadg1448.

PMID: 37205758 PMC: 10198638. DOI: 10.1126/sciadv.adg1448.

Sex-Biased Expression of Genes Allocated in the Autosomal Chromosomes: Blood LC-MS/MS Protein Profiling in Healthy Subjects.

Giha H, Abdulwahab R, Abbas J, Shinwari Z, Alaiya A Genet Res (Camb). 2023; 2023:8822205.

PMID: 36941947 PMC: 10024626. DOI: 10.1155/2023/8822205.

References

Garaud J, Schickel J, Blaison G, Knapp A, Dembele D, Ruer-Laventie J . B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus. PLoS One. 2011; 6(8):e23900. PMC: 3160348. DOI: 10.1371/journal.pone.0023900. View

Xie H, Hua C, Sun L, Zhao X, Fan H, Dou H . 17β-estradiol induces CD40 expression in dendritic cells via MAPK signaling pathways in a minichromosome maintenance protein 6-dependent manner. Arthritis Rheum. 2011; 63(8):2425-35. DOI: 10.1002/art.30420. View

Pogue S, Preston B, Stalder J, Bebbington C, Cardarelli P . The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res. 2004; 24(2):131-9. DOI: 10.1089/107999004322813372. View

Sankaran-Walters S, Macal M, Grishina I, Nagy L, Goulart L, Coolidge K . Sex differences matter in the gut: effect on mucosal immune activation and inflammation. Biol Sex Differ. 2013; 4(1):10. PMC: 3652739. DOI: 10.1186/2042-6410-4-10. View

Tian Y, Stamova B, Jickling G, Xu H, Liu D, Ander B . Y chromosome gene expression in the blood of male patients with ischemic stroke compared with male controls. Gend Med. 2012; 9(2):68-75.e3. PMC: 3454519. DOI: 10.1016/j.genm.2012.01.005. View

Oertelt-Prigione S . The influence of sex and gender on the immune response. Autoimmun Rev. 2011; 11(6-7):A479-85. DOI: 10.1016/j.autrev.2011.11.022. View

Straface E, Gambardella L, Brandani M, Malorni W . Sex differences at cellular level: "cells have a sex". Handb Exp Pharmacol. 2012; (214):49-65. DOI: 10.1007/978-3-642-30726-3_3. View

Uyama T, Jin X, Tsuboi K, Tonai T, Ueda N . Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochim Biophys Acta. 2009; 1791(12):1114-24. DOI: 10.1016/j.bbalip.2009.07.001. View

Sullivan N, Eickhoff C, Zhang X, Giddings O, Lane T, Hoft D . Importance of the CCR5-CCL5 axis for mucosal Trypanosoma cruzi protection and B cell activation. J Immunol. 2011; 187(3):1358-68. PMC: 3150841. DOI: 10.4049/jimmunol.1100033. View

10.

Zilbauer M, Jenke A, Wenzel G, Goedde D, Postberg J, Phillips A . Intestinal alpha-defensin expression in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2011; 17(10):2076-86. DOI: 10.1002/ibd.21577. View

11.

de Weerd N, Vivian J, Nguyen T, Mangan N, Gould J, Braniff S . Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1. Nat Immunol. 2013; 14(9):901-7. DOI: 10.1038/ni.2667. View

12.

Becker A, Dao K, Han B, Kornu R, Lakhanpal S, Mobley A . SLE peripheral blood B cell, T cell and myeloid cell transcriptomes display unique profiles and each subset contributes to the interferon signature. PLoS One. 2013; 8(6):e67003. PMC: 3691135. DOI: 10.1371/journal.pone.0067003. View

13.

Nadkarni S, McArthur S . Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity. Curr Opin Pharmacol. 2013; 13(4):576-81. DOI: 10.1016/j.coph.2013.05.007. View

14.

Kin N, Chen Y, Stefanov E, Gallo R, Kearney J . Cathelin-related antimicrobial peptide differentially regulates T- and B-cell function. Eur J Immunol. 2011; 41(10):3006-16. PMC: 3234162. DOI: 10.1002/eji.201141606. View

15.

Lee T, Chiang B . Sex differences in spontaneous versus induced animal models of autoimmunity. Autoimmun Rev. 2011; 11(6-7):A422-9. DOI: 10.1016/j.autrev.2011.11.020. View

16.

Serre K, Cunningham A, Coughlan R, Lino A, Rot A, Hub E . CD8 T cells induce T-bet-dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines. Blood. 2012; 120(23):4552-9. DOI: 10.1182/blood-2012-03-417733. View

17.

Guo C, Yang X, Wu Y, Yang L, Mi S, Liu Z . Involvement of caveolin-1 in the Jak-Stat signaling pathway and infectious spleen and kidney necrosis virus infection in mandarin fish (Siniperca chuatsi). Mol Immunol. 2011; 48(8):992-1000. PMC: 7112660. DOI: 10.1016/j.molimm.2011.01.001. View

18.

Garcia Verdecia B, Saavedra Hernandez D, Lorenzo-Luaces P, de Jesus Badia Alvarez T, Leonard Rupale I, Mazorra Herrera Z . Immunosenescence and gender: a study in healthy Cubans. Immun Ageing. 2013; 10(1):16. PMC: 3667016. DOI: 10.1186/1742-4933-10-16. View

19.

Choudhry M, Bland K, Chaudry I . Trauma and immune response--effect of gender differences. Injury. 2007; 38(12):1382-91. PMC: 2692838. DOI: 10.1016/j.injury.2007.09.027. View

20.

Kwekel J, Desai V, Moland C, Vijay V, Fuscoe J . Sex differences in kidney gene expression during the life cycle of F344 rats. Biol Sex Differ. 2013; 4(1):14. PMC: 3844475. DOI: 10.1186/2042-6410-4-14. View