Prevalence of Human Papillomavirus in Adolescent Girls Before Reported Sexual Debut

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2014 Apr 18

PMID 24740630

Citations 15

Authors

Catherine F Houlihan

Silvia de Sanjose

Kathy Baisley

John Changalucha

David A Ross

Saidi Kapiga

Jose M Godinez

Ivana Bozicevic

Richard J Hayes

Deborah Watson-Jones

Affiliations

Soon will be listed here.

Abstract

Background: Human papillomavirus (HPV) vaccines are recommended for girls prior to sexual debut because they are most effective if administered before girls acquire HPV. Little research has been done on HPV prevalence in girls who report not having passed sexual debut in high HPV-prevalence countries.

Methods: Using attendance registers of randomly selected primary schools in the Mwanza region of Tanzania, we enrolled girls aged 15-16 years who reported not having passed sexual debut. A face-to-face interview on sexual behavior and intravaginal practices, and a nurse-assisted self-administered vaginal swab were performed. Swabs were tested for 13 high-risk and 24 low-risk HPV genotypes.

Results: HPV was detected in 40/474 (8.4%; 95% confidence interval [CI], 5.9-11.0) girls. Ten different high-risk and 21 different low-risk genotypes were detected. High-risk genotypes were detected in 5.3% (95% CI, 3.5-7.8). In multivariable analysis, only intravaginal cleansing (practiced by 20.9%) was associated with HPV detection (adjusted odds ratio = 2.19, 95% CI, 1.09-4.39).

Conclusion: This cohort of adolescent Tanzanian girls had a high HPV prevalence prior to self-reported sexual debut, and this was associated with intravaginal cleansing. This most likely reflects underreporting of sexual activity, and it is possible that intravaginal cleansing is a marker for unreported sexual debut or nonpenetrative sexual behaviors.

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Sexual Practices During Adolescence.

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The Vaginal Microbiota Among Adolescent Girls in Tanzania Around the Time of Sexual Debut.

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