Snake Venom L-amino Acid Oxidases: Trends in Pharmacology and Biochemistry

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Apr 17

PMID 24738050

Citations 57

Authors

Luiz Fernando M Izidoro

Juliana C Sobrinho

Mirian M Mendes

Tassia R Costa

Amy N Grabner

Veridiana M Rodrigues

Saulo L da Silva

Fernando B Zanchi

Juliana P Zuliani

Carla F C Fernandes

Leonardo A Calderon

Rodrigo G Stabeli

Andreimar M Soares

Affiliations

Soon will be listed here.

Abstract

L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases exert biological and pharmacological effects, including actions on platelet aggregation and the induction of apoptosis, hemorrhage, and cytotoxicity. These proteins present a high biotechnological potential for the development of antimicrobial, antitumor, and antiprotozoan agents. This review provides an overview of the biochemical properties and pharmacological effects of snake venom L-amino acid oxidases, their structure/activity relationship, and supposed mechanisms of action described so far.

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