The Green Tea Extract Epigallocatechin-3-gallate Inhibits Irradiation-induced Pulmonary Fibrosis in Adult Rats

Overview

Journal Int J Mol Med

Specialty Genetics

Date 2014 Apr 17

PMID 24736877

Citations 29

Authors

Hua You

Li Wei

Wan-Liang Sun

Lei Wang

Zai-Liang Yang

Yuan Liu

Ke Zheng

Ying Wang

Wei-Jing Zhang

Affiliations

Soon will be listed here.

Abstract

Nad(p)h: quinone oxidoreductase-1 (NQO-1) were examined via western blot analysis. Treatment with EGCG, but not DEX, reduced mortality rates and lung index scores, improved histological changes in the lung, reduced collagen depositions, reduced MDA content, enhanced SOD activity, inhibited (myo)fibroblast proliferation, protected alveolar epithelial type II (AE2) cells, and regulated serum levels of TGF-β1, IL-6, IL-10, and TNF-α. Treatment with EGCG, but not DEX, activated Nrf-2 and its downstream antioxidant enzymes HO-1 and NQO-1. Taken together, these results showed that EGCG treatment significantly inhibits irradiation-induced pulmonary fibrosis. Furthermore, the results suggested promising clinical EGCG therapies to treat this disorder.

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References

Sriram N, Kalayarasan S, Sudhandiran G . Epigallocatechin-3-gallate exhibits anti-fibrotic effect by attenuating bleomycin-induced glycoconjugates, lysosomal hydrolases and ultrastructural changes in rat model pulmonary fibrosis. Chem Biol Interact. 2009; 180(2):271-80. DOI: 10.1016/j.cbi.2009.02.017. View

Williams J, Johnston C, Finkelstein J . Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?. Curr Drug Targets. 2010; 11(11):1386-94. PMC: 2948640. DOI: 10.2174/1389450111009011386. View

de Vries H, Witte M, Hondius D, Rozemuller A, Drukarch B, Hoozemans J . Nrf2-induced antioxidant protection: a promising target to counteract ROS-mediated damage in neurodegenerative disease?. Free Radic Biol Med. 2008; 45(10):1375-83. DOI: 10.1016/j.freeradbiomed.2008.09.001. View

Schaue D, Kachikwu E, McBride W . Cytokines in radiobiological responses: a review. Radiat Res. 2012; 178(6):505-23. PMC: 3723384. DOI: 10.1667/RR3031.1. View

Hugel H, Jackson N . Redox chemistry of green tea polyphenols: therapeutic benefits in neurodegenerative diseases. Mini Rev Med Chem. 2012; 12(5):380-7. DOI: 10.2174/138955712800493906. View

Minor G, Yashar C, Spanos Jr W, Jose B, Silverman C, Carrascosa L . The relationship of radiation pneumonitis to treated lung volume in breast conservation therapy. Breast J. 2006; 12(1):48-52. DOI: 10.1111/j.1075-122X.2006.00180.x. View

Mak J . Potential role of green tea catechins in various disease therapies: progress and promise. Clin Exp Pharmacol Physiol. 2012; 39(3):265-73. DOI: 10.1111/j.1440-1681.2012.05673.x. View

Dong X, Wang J, Liu L, Chen X, Chen M, Chen J . Modulation of radiation-induced tumour necrosis factor-α and transforming growth factor β1 expression in the lung tissue by Shengqi Fuzheng injection. Mol Med Rep. 2011; 3(4):621-7. DOI: 10.3892/mmr_00000306. View

Zhang Y, Zhang X, Rabbani Z, Jackson I, Vujaskovic Z . Oxidative stress mediates radiation lung injury by inducing apoptosis. Int J Radiat Oncol Biol Phys. 2012; 83(2):740-8. PMC: 3649017. DOI: 10.1016/j.ijrobp.2011.08.005. View

10.

Bae H, Li M, Kim J, Kim S, Jeong C, Lee H . The effect of epigallocatechin gallate on lipopolysaccharide-induced acute lung injury in a murine model. Inflammation. 2009; 33(2):82-91. DOI: 10.1007/s10753-009-9161-z. View

11.

Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K, Ueki N . Dose--volume metrics associated with radiation pneumonitis after stereotactic body radiation therapy for lung cancer. Int J Radiat Oncol Biol Phys. 2012; 83(4):e545-9. DOI: 10.1016/j.ijrobp.2012.01.018. View

12.

Sahin K, Tuzcu M, Gencoglu H, Dogukan A, Timurkan M, Sahin N . Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats. Life Sci. 2010; 87(7-8):240-5. DOI: 10.1016/j.lfs.2010.06.014. View

13.

Martin M, Lefaix J, Delanian S . TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?. Int J Radiat Oncol Biol Phys. 2000; 47(2):277-90. DOI: 10.1016/s0360-3016(00)00435-1. View

14.

Epperly M, Guo H, Gretton J, Greenberger J . Bone marrow origin of myofibroblasts in irradiation pulmonary fibrosis. Am J Respir Cell Mol Biol. 2003; 29(2):213-24. DOI: 10.1165/rcmb.2002-0069OC. View

15.

Zhang Y, Fu S, Li X, Chen P, Wang J, Che J . PEP-1-SOD1 protects brain from ischemic insult following asphyxial cardiac arrest in rats. Resuscitation. 2011; 82(8):1081-6. PMC: 3138811. DOI: 10.1016/j.resuscitation.2011.01.034. View

16.

Barbarin V, Xing Z, Delos M, Lison D, Huaux F . Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles. Am J Physiol Lung Cell Mol Physiol. 2004; 288(5):L841-8. DOI: 10.1152/ajplung.00329.2004. View

17.

Rosenzweig K, Zauderer M, Laser B, Krug L, Yorke E, Sima C . Pleural intensity-modulated radiotherapy for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2012; 83(4):1278-83. PMC: 4359620. DOI: 10.1016/j.ijrobp.2011.09.027. View

18.

Li C, Yao J, Tao Z, Li X, Jiang Q, Yan B . Epigallocatechin-gallate (EGCG) regulates autophagy in human retinal pigment epithelial cells: a potential role for reducing UVB light-induced retinal damage. Biochem Biophys Res Commun. 2013; 438(4):739-45. DOI: 10.1016/j.bbrc.2013.07.097. View

19.

Tipoe G, Leung T, Liong E, Lau T, Fung M, Nanji A . Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice. Toxicology. 2010; 273(1-3):45-52. DOI: 10.1016/j.tox.2010.04.014. View

20.

Wang J, Qiao X, Lu F, Zhou Z, Song Y, Huo J . TGF-beta1 in serum and induced sputum for predicting radiation pneumonitis in patients with non-small cell lung cancer after radiotherapy. Chin J Cancer. 2010; 29(3):325-9. DOI: 10.5732/cjc.009.10454. View