Delineation of Candidate Genes Responsible for Structural Brain Abnormalities in Patients with Terminal Deletions of Chromosome 6q27

Overview

Journal Eur J Hum Genet

Specialty Genetics

Date 2014 Apr 17

PMID 24736736

Citations 26

Authors

Sirisha Peddibhotla

Sandesh C S Nagamani

Ayelet Erez

Jill V Hunter

J Lloyd Holder Jr

Mary E Carlin

Patricia I Bader

Helene M F Perras

Judith E Allanson

Leslie Newman

Gayle Simpson

LaDonna Immken

Erin Powell

Aaron Mohanty

Sung-Hae L Kang

Pawel Stankiewicz

Carlos A Bacino

Weimin Bi

Ankita Patel

Sau W Cheung

Affiliations

Soon will be listed here.

Abstract

Patients with terminal deletions of chromosome 6q present with structural brain abnormalities including agenesis of corpus callosum, hydrocephalus, periventricular nodular heterotopia, and cerebellar malformations. The 6q27 region harbors genes that are important for the normal development of brain and delineation of a critical deletion region for structural brain abnormalities may lead to a better genotype-phenotype correlation. We conducted a detailed clinical and molecular characterization of seven unrelated patients with deletions involving chromosome 6q27. All patients had structural brain abnormalities. Using array comparative genomic hybridization, we mapped the size, extent, and genomic content of these deletions. The smallest region of overlap spans 1.7 Mb and contains DLL1, THBS2, PHF10, and C6orf70 (ERMARD) that are plausible candidates for the causation of structural brain abnormalities. Our study reiterates the importance of 6q27 region in normal development of brain and helps identify putative genes in causation of structural brain anomalies.

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