Component Analysis of Iranian Crack; a Newly Abused Narcotic Substance in Iran

Overview

Journal Iran J Pharm Res

Publisher Brieflands

Specialty Pharmacology

Date 2014 Apr 16

PMID 24734089

Citations 12

Authors

Ali Farhoudian

Mandana Sadeghi

Hamid Reza Khoddami Vishteh

Babak Moazen

Monir Fekri

Afarin Rahimi Movaghar

Affiliations

Soon will be listed here.

Abstract

Iranian crack is a new form of narcotic substance that has found widespread prevalence in Iran in the past years. Crack only nominally resembles crack cocaine as it is widely different in its clinical signs. Thus the present study aims to quantify the chemical combination of this drug. The samples included 18 specimen of Crack collected from different zones of Tehran, Iran. All specimens were in the form of inodorous cream solid powdery substance. TLC and HPLC methods were used to perform semi-quantitative and quantitative analysis of the components, respectively. The TLC analysis showed no cocaine compound in the specimens while they all revealed to contain heroin, codeine, morphine and caffeine. All but two specimens contained thebaine. None of the specimens contained amphetamine, benzodiazepines, tricyclic antidepressants, aspirin, barbiturates, tramadol and buprenorphine. Acetaminophen was found in four specimens. HPLC revealed heroin to be the foundation substance in all specimens and most of them contained a significant amount of acetylcodeine. The present analysis of the chemical combination of Crack showed that this substance is a heroin-based narcotic which is basically different from the cocaine-based crack used in Western countries. Studies like the present one at different time points, especially when abnormal clinical signs are detected, can reveal the chemical combination of the target substance and contribute to the clinical management of its acute or chronic poisoning.

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References

Huizer H . Analytical studies on illicit heroin. I. The occurrence of O3-monoacetylmorphine. J Forensic Sci. 1983; 28(1):32-9. View

Eskes D, Brown J . Herion-caffeine-strychnine mixtures--where and why?. Bull Narc. 1975; 27(1):67-9. View

Souri E, Hatami A, Ravari N, Alvandifar F, Tehrani M . Validating a stability indicating HPLC method for kinetic study of cetirizine degradation in acidic and oxidative conditions. Iran J Pharm Res. 2013; 12(2):287-94. PMC: 3813251. View

Narenjiha H, Rafiey H, Reza Jahani M, Assari S, Moharamzad Y, Roshanpazooh M . Substance-dependent professional drivers in Iran: a descriptive study. Traffic Inj Prev. 2009; 10(3):227-30. DOI: 10.1080/15389580902849017. View

ONeil P, BAKER P, GOUGH T . Illicitly imported heroin products: some physical and chemical features indicative of their origin. J Forensic Sci. 1984; 29(3):889-902. View

ONeal C, Poklis A . The detection of acetylcodeine and 6-acetylmorphine in opiate positive urines. Forensic Sci Int. 1998; 95(1):1-10. DOI: 10.1016/s0379-0738(98)00074-7. View

Oliveira L, de Carvalho Ponce J, Nappo S . Crack cocaine use in Barcelona: a reason of worry. Subst Use Misuse. 2010; 45(13):2291-300. DOI: 10.3109/10826081003682883. View

ONeal C, Poklis A, Lichtman A . Acetylcodeine, an impurity of illicitly manufactured heroin, elicits convulsions, antinociception, and locomotor stimulation in mice. Drug Alcohol Depend. 2001; 65(1):37-43. DOI: 10.1016/s0376-8716(01)00145-4. View

Johnson D, Gunn Jr J . Dangerous drugs: adulterants, diluents, and deception in street samples. J Forensic Sci. 1972; 17(4):629-39. View

10.

Razani N, Mohraz M, Kheirandish P, Malekinejad M, Malekafzali H, Mokri A . HIV risk behavior among injection drug users in Tehran, Iran. Addiction. 2007; 102(9):1472-82. DOI: 10.1111/j.1360-0443.2007.01914.x. View

11.

Phillips S, Allen K . Acetylcodeine as a marker of illicit heroin abuse in oral fluid samples. J Anal Toxicol. 2006; 30(6):370-4. DOI: 10.1093/jat/30.6.370. View

12.

Dams R, Benijts T, Lambert W, Massart D, De Leenheer A . Heroin impurity profiling: trends throughout a decade of experimenting. Forensic Sci Int. 2001; 123(2-3):81-8. DOI: 10.1016/s0379-0738(01)00541-2. View

13.

Klemenc S . Noscapine as an adulterant in illicit heroin samples. Forensic Sci Int. 2000; 108(1):45-9. DOI: 10.1016/s0379-0738(99)00201-7. View

14.

Soine W . Clandestine drug synthesis. Med Res Rev. 1986; 6(1):41-74. DOI: 10.1002/med.2610060103. View

15.

Vaughn M, Fu Q, Perron B, Bohnert A, Howard M . Is crack cocaine use associated with greater violence than powdered cocaine use? Results from a national sample. Am J Drug Alcohol Abuse. 2010; 36(4):181-6. DOI: 10.3109/00952990.2010.491877. View

16.

Narayanaswami K . Parameters for determining the origin of illicit heroin samples. Bull Narc. 1985; 37(1):49-62. View

17.

Huizer H . Analytical studies on illicit heroin. II. Comparison of samples. J Forensic Sci. 1983; 28(1):40-8. View

18.

Odovic J, Karljikovic-Rajic K, Trbojevic-Stankovic J, Stojimirovic B, Vladimirov S . Lipophilicity Examination of Some ACE inhibitors andHydrochlorothiazide on Cellulose in RP Thin-Layer Chromatography. Iran J Pharm Res. 2013; 11(3):763-70. PMC: 3813140. View

19.

Kaa E, Bent K . Impurities, adulterants and diluents of illicit heroin in Denmark (Jutland and Funen). Forensic Sci Int. 1986; 31(3):195-210. DOI: 10.1016/0379-0738(86)90188-x. View

20.

van der Slooten E, VAN DER HELM H . Analysis of heroin in relation to illicit drug traffic. Forensic Sci. 1975; 6(1-2):83-8. DOI: 10.1016/0300-9432(75)90226-5. View