Paraneoplastic Neuromyelitis Optica Spectrum Disorder Associated with Metastatic Carcinoid Expressing Aquaporin-4

Overview

Journal JAMA Neurol

Publisher American Medical Association

Date 2014 Apr 16

PMID 24733266

Citations 19

Authors

Michelle Figueroa

Yong Guo

Alexandros Tselis

Sean J Pittock

Vanda A Lennon

Claudia F Lucchinetti

Robert P Lisak

Affiliations

Soon will be listed here.

Abstract

Importance: Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis.

Observations: In this case report, we describe a patient with NMOSD whose test results were seropositive for aquaporin-4 IgG and who had a hepatic metastasis from a small-bowel neuroendocrine tumor. The tumor cells expressed aquaporin-4 immunoreactivity. She presented to the Neurology Department at Wayne State University with bilateral leg weakness, ascending paresthesias, and decreased sensation.

Conclusions And Relevance: This case extends the context of NMOSD as a paraneoplastic disorder.

Citing Articles

Neuromyelitis optica spectrum disorder: Exploring the diverse clinical manifestations and the need for further exploration.

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Neurological autoimmunity in patients with non-pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles.

Mangioris G, Halfdanarson T, Lennon V, Chang B, Dubey D, Dyck P Eur J Neurol. 2024; 31(6):e16273.

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The temporal relationship of paraneoplastic aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorder (NMOSD) and breast cancer: a systematic review and meta-analysis.

Srichawla B, Doshi K, Cheraghi S, Sivakumar S Neurol Sci. 2023; 44(11):3809-3817.

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Aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder with cholangiocarcinoma: Casual or causal association?.

Fang W, Tang J, Lin B, Lai Q, Cai M, Liu Z CNS Neurosci Ther. 2022; 29(2):749-751.

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Neuroimaging features in inflammatory myelopathies: A review.

Cacciaguerra L, Sechi E, Rocca M, Filippi M, Pittock S, Flanagan E Front Neurol. 2022; 13:993645.

PMID: 36330423 PMC: 9623025. DOI: 10.3389/fneur.2022.993645.

References

Pittock S, Kryzer T, Lennon V . Paraneoplastic antibodies coexist and predict cancer, not neurological syndrome. Ann Neurol. 2004; 56(5):715-9. DOI: 10.1002/ana.20269. View

Flanagan E, McKeon A, Lennon V, Kearns J, Weinshenker B, Krecke K . Paraneoplastic isolated myelopathy: clinical course and neuroimaging clues. Neurology. 2011; 76(24):2089-95. DOI: 10.1212/WNL.0b013e31821f468f. View

Pittock S, Lucchinetti C, Parisi J, Benarroch E, Mokri B, Stephan C . Amphiphysin autoimmunity: paraneoplastic accompaniments. Ann Neurol. 2005; 58(1):96-107. DOI: 10.1002/ana.20529. View

Dalmau J, Rosenfeld M . Paraneoplastic syndromes of the CNS. Lancet Neurol. 2008; 7(4):327-40. PMC: 2367117. DOI: 10.1016/S1474-4422(08)70060-7. View

Quek A, McKeon A, Lennon V, Mandrekar J, Iorio R, Jiao Y . Effects of age and sex on aquaporin-4 autoimmunity. Arch Neurol. 2012; 69(8):1039-43. PMC: 3746965. DOI: 10.1001/archneurol.2012.249. View

Frigeri A, Gropper M, Umenishi F, Kawashima M, Brown D, Verkman A . Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues. J Cell Sci. 1995; 108 ( Pt 9):2993-3002. DOI: 10.1242/jcs.108.9.2993. View

Keegan B, Pittock S, Lennon V . Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G. Ann Neurol. 2008; 63(4):531-4. DOI: 10.1002/ana.21324. View

Cross S, Salomao D, Parisi J, Kryzer T, Bradley E, Mines J . Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol. 2003; 54(1):38-50. DOI: 10.1002/ana.10587. View

Wingerchuk D, Lennon V, Lucchinetti C, Pittock S, Weinshenker B . The spectrum of neuromyelitis optica. Lancet Neurol. 2007; 6(9):805-15. DOI: 10.1016/S1474-4422(07)70216-8. View

10.

Pittock S, Lennon V, De Seze J, Vermersch P, Homburger H, Wingerchuk D . Neuromyelitis optica and non organ-specific autoimmunity. Arch Neurol. 2008; 65(1):78-83. DOI: 10.1001/archneurol.2007.17. View

11.

Hinson S, McKeon A, Lennon V . Neurological autoimmunity targeting aquaporin-4. Neuroscience. 2009; 168(4):1009-18. DOI: 10.1016/j.neuroscience.2009.08.032. View

12.

Frasquet M, Bataller L, Torres-Vega E, Duran-Moreno M, Garcia-Verdugo J, Sevilla T . Longitudinally extensive transverse myelitis with AQP4 antibodies revealing ovarian teratoma. J Neuroimmunol. 2013; 263(1-2):145-7. DOI: 10.1016/j.jneuroim.2013.07.003. View

13.

Frigeri A, Gropper M, Turck C, Verkman A . Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci U S A. 1995; 92(10):4328-31. PMC: 41937. DOI: 10.1073/pnas.92.10.4328. View

14.

McKeon A, Lennon V, Jacob A, Matiello M, Lucchinetti C, Kale N . Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica. Muscle Nerve. 2008; 39(1):87-90. DOI: 10.1002/mus.21197. View

15.

De Santis G, Caniatti L, De Vito A, De Gennaro R, Granieri E, Tola M . A possible paraneoplastic neuromyelitis optica associated with lung cancer. Neurol Sci. 2009; 30(5):397-400. DOI: 10.1007/s10072-009-0112-0. View

16.

Armagan H, Tuzun E, Icoz S, Birisik O, Ulusoy C, Demir G . Long extensive transverse myelitis associated with aquaporin-4 antibody and breast cancer: favorable response to cancer treatment. J Spinal Cord Med. 2012; 35(4):267-9. PMC: 3425884. DOI: 10.1179/2045772312Y.0000000018. View

17.

Pittock S, Lennon V . Aquaporin-4 autoantibodies in a paraneoplastic context. Arch Neurol. 2008; 65(5):629-32. DOI: 10.1001/archneur.65.5.629. View

18.

Iorio R, Lennon V . Neural antigen-specific autoimmune disorders. Immunol Rev. 2012; 248(1):104-21. DOI: 10.1111/j.1600-065X.2012.01144.x. View

19.

Collongues N, Marignier R, Zephir H, Papeix C, Blanc F, Ritleng C . Neuromyelitis optica in France: a multicenter study of 125 patients. Neurology. 2010; 74(9):736-42. DOI: 10.1212/WNL.0b013e3181d31e35. View