Serum Interleukin-17 As a Diagnostic and Prognostic Marker for Non-small Cell Lung Cancer

Overview

Journal Biomarkers

Specialty Biochemistry

Date 2014 Apr 16

PMID 24731052

Citations 40

Authors

Chunhua Xu

Keke Hao

Like Yu

Xiuwei Zhang

Affiliations

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Abstract

Objective: The aim of this study was to explore the clinical role of serum interleukin (IL)-17 in patients with non-small-cell lung cancer (NSCLC).

Materials And Method: Serum specimens from 128 patients with NSCLC and 60 healthy controls were collected. The concentrations of IL-17 were measured using enzyme-linked immunosorbent assay.

Results: Serum IL-17 levels were higher in the NSCLC group in comparison with the control group (p < 0.01). With a cut-off value of 16 pg/ml, IL-17 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that IL-17 was an independent prognostic factor in NSCLC.

Conclusion: Measurement of IL-17 might be a useful diagnostic and prognostic value for patients with NSCLC.

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