Non-invasive Assessment of Carotid PWV Via Accelerometric Sensors: Validation of a New Device and Comparison with Established Techniques

Overview

Journal Eur J Appl Physiol

Specialty Physiology

Date 2014 Apr 15

PMID 24728548

Citations 4

Authors

Nicole Di Lascio

Rosa Maria Bruno

Francesco Stea

Elisabetta Bianchini

Vincenzo Gemignani

Lorenzo Ghiadoni

Francesco Faita

Affiliations

Soon will be listed here.

Abstract

Purpose: Carotid pulse wave velocity (PWV) is considered as a surrogate marker for carotid stiffness and its assessment is increasingly being used in clinical practice. However, at the moment, its estimation needs specific equipment and a moderate level of technical expertise; moreover, it is based on a mathematical model. The aim of this study was to validate a new system for non-invasive and model-free carotid PWV assessment based on accelerometric sensors by comparison with currently used techniques.

Methods: Accelerometric PWV (accPWV) values were obtained in 97 volunteers free of cardiovascular disease (age 24-85 years) and compared with standard ultrasound-based carotid stiffness parameters, such as carotid PWV (cPWV), relative distension (relD) and distensibility coefficient (DC). Moreover, the comparison between accPWV measurements and carotid-femoral PWV (cfPWV) was performed.

Results: Accelerometric PWV evaluations showed a significant correlation with cPWV measurements (R = 0.67), relD values (R = 0.66) and DC assessments (R = 0.64). These values were also significantly correlated with cfPWV evaluations (R = 0.46). In addition, the first attempt success rate was equal to 76.8 %.

Conclusions: The accelerometric system allows a simple and quick local carotid stiffness evaluation and the values obtained with this system are significantly correlated with known carotid stiffness biomarkers. Therefore, the presented device could provide a concrete opportunity for an easy carotid stiffness evaluation even in clinical practice.

Citing Articles

A Flexible Ultrasound Array for Local Pulse Wave Velocity Monitoring.

Xu L, Wang P, Xia P, Wu P, Chen X, Du L Biosensors (Basel). 2022; 12(7).

PMID: 35884282 PMC: 9312981. DOI: 10.3390/bios12070479.

Carotid Pulse Wave Analysis: Future Direction of Hemodynamic and Cardiovascular Risk Assessment.

Parittotokkaporn S, de Castro D, Lowe A, Pylypchuk R JMA J. 2021; 4(2):119-128.

PMID: 33997445 PMC: 8119021. DOI: 10.31662/jmaj.2020-0108.

Weight Loss After Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity.

Giudici A, Palombo C, Kozakova M, Morizzo C, Losso L, Nannipieri M Obes Surg. 2020; 30(10):3776-3783.

PMID: 32495072 PMC: 7651614. DOI: 10.1007/s11695-020-04686-y.

Pulse Wave Velocities Derived From Cuff Ambulatory Pulse Wave Analysis.

Schwartz J, Feig P, Izzo Jr J Hypertension. 2019; 74(1):111-116.

PMID: 31132952 PMC: 6679929. DOI: 10.1161/HYPERTENSIONAHA.119.12756.

References

Bland J, Altman D . Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986; 1(8476):307-10. View

Giannattasio C, Salvi P, Valbusa F, Kearney-Schwartz A, Capra A, Amigoni M . Simultaneous measurement of beat-to-beat carotid diameter and pressure changes to assess arterial mechanical properties. Hypertension. 2008; 52(5):896-902. DOI: 10.1161/HYPERTENSIONAHA.108.116509. View

Dijk J, Algra A, van der Graaf Y, Grobbee D, Bots M . Carotid stiffness and the risk of new vascular events in patients with manifest cardiovascular disease. The SMART study. Eur Heart J. 2005; 26(12):1213-20. DOI: 10.1093/eurheartj/ehi254. View

Vlachopoulos C, Aznaouridis K, Stefanadis C . Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010; 55(13):1318-27. DOI: 10.1016/j.jacc.2009.10.061. View

Brands P, Hoeks A, Willigers J, Willekes C, Reneman R . An integrated system for the non-invasive assessment of vessel wall and hemodynamic properties of large arteries by means of ultrasound. Eur J Ultrasound. 2000; 9(3):257-66. DOI: 10.1016/s0929-8266(99)00033-6. View

Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, Guize L . Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension. 2001; 37(5):1236-41. DOI: 10.1161/01.hyp.37.5.1236. View

Nemeth Z, Studinger P, Kiss I, El Hadj Othmane T, Nemcsik J, Fekete B . The method of distance measurement and torso length influences the relationship of pulse wave velocity to cardiovascular mortality. Am J Hypertens. 2010; 24(2):155-61. DOI: 10.1038/ajh.2010.220. View

Bianchini E, Bozec E, Gemignani V, Faita F, Giannarelli C, Ghiadoni L . Assessment of carotid stiffness and intima-media thickness from ultrasound data: comparison between two methods. J Ultrasound Med. 2010; 29(8):1169-75. DOI: 10.7863/jum.2010.29.8.1169. View

Westenberg J, van Poelgeest E, Steendijk P, Grotenhuis H, Jukema J, de Roos A . Bramwell-Hill modeling for local aortic pulse wave velocity estimation: a validation study with velocity-encoded cardiovascular magnetic resonance and invasive pressure assessment. J Cardiovasc Magn Reson. 2012; 14:2. PMC: 3312851. DOI: 10.1186/1532-429X-14-2. View

10.

Laurent S . Arterial stiffness in arterial hypertension. Curr Hypertens Rep. 2006; 8(3):179-80. DOI: 10.1007/s11906-006-0047-2. View

11.

Laurent S, Katsahian S, Fassot C, Tropeano A, Gautier I, Laloux B . Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke. 2003; 34(5):1203-6. DOI: 10.1161/01.STR.0000065428.03209.64. View

12.

Davies J, Whinnett Z, Francis D, Willson K, Foale R, Malik I . Use of simultaneous pressure and velocity measurements to estimate arterial wave speed at a single site in humans. Am J Physiol Heart Circ Physiol. 2005; 290(2):H878-85. DOI: 10.1152/ajpheart.00751.2005. View

13.

Salvi P, Lio G, Labat C, Ricci E, Pannier B, Benetos A . Validation of a new non-invasive portable tonometer for determining arterial pressure wave and pulse wave velocity: the PulsePen device. J Hypertens. 2004; 22(12):2285-93. DOI: 10.1097/00004872-200412000-00010. View

14.

Pannier B, Avolio A, Hoeks A, Mancia G, Takazawa K . Methods and devices for measuring arterial compliance in humans. Am J Hypertens. 2002; 15(8):743-53. DOI: 10.1016/s0895-7061(02)02962-x. View

15.

Mattace-Raso F, van der Cammen T, Hofman A, van Popele N, Bos M, Schalekamp M . Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation. 2006; 113(5):657-63. DOI: 10.1161/CIRCULATIONAHA.105.555235. View

16.

Hermeling E, Reesink K, Kornmann L, Reneman R, Hoeks A . The dicrotic notch as alternative time-reference point to measure local pulse wave velocity in the carotid artery by means of ultrasonography. J Hypertens. 2009; 27(10):2028-35. DOI: 10.1097/HJH.0b013e32832f5890. View

17.

Barenbrock M, Kosch M, Joster E, Kisters K, Rahn K, Hausberg M . Reduced arterial distensibility is a predictor of cardiovascular disease in patients after renal transplantation. J Hypertens. 2002; 20(1):79-84. DOI: 10.1097/00004872-200201000-00012. View

18.

Giannarelli C, Bianchini E, Bruno R, Magagna A, Landini L, Faita F . Local carotid stiffness and intima-media thickness assessment by a novel ultrasound-based system in essential hypertension. Atherosclerosis. 2012; 223(2):372-7. DOI: 10.1016/j.atherosclerosis.2012.05.027. View

19.

Oliver J, Webb D . Noninvasive assessment of arterial stiffness and risk of atherosclerotic events. Arterioscler Thromb Vasc Biol. 2003; 23(4):554-66. DOI: 10.1161/01.ATV.0000060460.52916.D6. View

20.

Pan J, Tompkins W . A real-time QRS detection algorithm. IEEE Trans Biomed Eng. 1985; 32(3):230-6. DOI: 10.1109/TBME.1985.325532. View