Nanosized Mesoporous Bioactive Glass/poly(lactic-co-glycolic Acid) Composite-coated CaSiO3 Scaffolds with Multifunctional Properties for Bone Tissue Engineering

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Apr 12

PMID 24724080

Citations 7

Authors

Mengchao Shi

Dong Zhai

Lang Zhao

Chengtie Wu

Jiang Chang

Affiliations

Soon will be listed here.

Abstract

It is of great importance to prepare multifunctional scaffolds combining good mechanical strength, bioactivity, and drug delivery ability for bone tissue engineering. In this study, nanosized mesoporous bioglass/poly(lactic-co-glycolic acid) composite-coated calcium silicate scaffolds, named NMBG-PLGA/CS, were successfully prepared. The morphology and structure of the prepared scaffolds were characterized by scanning electron microscopy and X-ray diffraction. The effects of NMBG on the apatite mineralization activity and mechanical strength of the scaffolds and the attachment, proliferation, and alkaline phosphatase activity of MC3T3 cells as well as drug ibuprofen delivery properties were systematically studied. Compared to pure CS scaffolds and PLGA/CS scaffolds, the prepared NMBG-PLGA/CS scaffolds had greatly improved apatite mineralization activity in simulated body fluids, much higher mechanical property, and supported the attachment of MC3T3 cells and enhanced the cell proliferation and ALP activity. Furthermore, the prepared NMBG-PLGA/CS scaffolds could be used for delivering ibuprofen with a sustained release profile. Our study suggests that the prepared NMBG-PLGA/CS scaffolds have improved physicochemical, biological, and drug-delivery property as compared to conventional CS scaffolds, indicating that the multifunctional property of the prepared scaffolds for the potential application of bone tissue engineering.

Citing Articles

Fabrication and characterizations of simvastatin-containing mesoporous bioactive glass and molybdenum disulfide scaffold for bone tissue engineering.

Murugan S, Appana Dalavi P, Surya S, Anil S, Gupta S, Shetty R APL Bioeng. 2023; 7(4):046115.

PMID: 38058994 PMC: 10697724. DOI: 10.1063/5.0172002.

Enhanced Osteogenic Activity and Bone Repair Ability of PLGA/MBG Scaffolds Doped with ZIF-8 Nanoparticles Loaded with BMP-2.

Ma R, Su Y, Cao R, Wang K, Yang P Int J Nanomedicine. 2023; 18:5055-5072.

PMID: 37701821 PMC: 10493152. DOI: 10.2147/IJN.S423985.

MBG/ PGA-PCL composite scaffolds provide highly tunable degradation and osteogenic features.

Li J, Wang C, Gao G, Yin X, Pu X, Shi B Bioact Mater. 2022; 15:53-67.

PMID: 35386352 PMC: 8941175. DOI: 10.1016/j.bioactmat.2021.11.034.

Biocompatible Nanobioglass Reinforced Poly(ε-Caprolactone) Composites Synthesized via In Situ Ring Opening Polymerization.

Terzopoulou Z, Baciu D, Gounari E, Steriotis T, Charalambopoulou G, Bikiaris D Polymers (Basel). 2019; 10(4).

PMID: 30966416 PMC: 6415238. DOI: 10.3390/polym10040381.

[Research progress on mesoporous bioactive glass].

Wu J, Yang L, Li Y, Guo L Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2018; 35(4):647-650.

PMID: 30124031 PMC: 9935119. DOI: 10.7507/1001-5515.201706091.

References

Wu C, Ramaswamy Y, Boughton P, Zreiqat H . Improvement of mechanical and biological properties of porous CaSiO3 scaffolds by poly(D,L-lactic acid) modification. Acta Biomater. 2007; 4(2):343-53. DOI: 10.1016/j.actbio.2007.08.010. View

Wang C, Lin K, Chang J, Sun J . Osteogenesis and angiogenesis induced by porous β-CaSiO(3)/PDLGA composite scaffold via activation of AMPK/ERK1/2 and PI3K/Akt pathways. Biomaterials. 2012; 34(1):64-77. DOI: 10.1016/j.biomaterials.2012.09.021. View

Ni S, Lin K, Chang J, Chou L . Beta-CaSiO3/beta-Ca3(PO4)2 composite materials for hard tissue repair: in vitro studies. J Biomed Mater Res A. 2007; 85(1):72-82. DOI: 10.1002/jbm.a.31390. View

Wu C, Chang J, Xiao Y . Mesoporous bioactive glasses as drug delivery and bone tissue regeneration platforms. Ther Deliv. 2012; 2(9):1189-98. DOI: 10.4155/tde.11.84. View

Wu C, Miron R, Sculean A, Kaskel S, Doert T, Schulze R . Proliferation, differentiation and gene expression of osteoblasts in boron-containing associated with dexamethasone deliver from mesoporous bioactive glass scaffolds. Biomaterials. 2011; 32(29):7068-78. DOI: 10.1016/j.biomaterials.2011.06.009. View

Quan Z, Han X, Ye Z, Chenzhong Y, Wenjun C . Influence of novel nano-mesoporous bioactive glass on the regulation of IGF-II gene expression in osteoblasts. Cell Biochem Biophys. 2011; 62(1):119-23. DOI: 10.1007/s12013-011-9269-2. View

De Aza P, Guitian F, De Aza S, Valle F . Analytical control of wollastonite for biomedical applications by use of atomic absorption spectrometry and inductively coupled plasma atomic emission spectrometry. Analyst. 1998; 123(4):681-5. DOI: 10.1039/a708445e. View

Ni S, Chang J, Chou L, Zhai W . Comparison of osteoblast-like cell responses to calcium silicate and tricalcium phosphate ceramics in vitro. J Biomed Mater Res B Appl Biomater. 2006; 80(1):174-83. DOI: 10.1002/jbm.b.30582. View

Wu C, Zhou Y, Fan W, Han P, Chang J, Yuen J . Hypoxia-mimicking mesoporous bioactive glass scaffolds with controllable cobalt ion release for bone tissue engineering. Biomaterials. 2011; 33(7):2076-85. DOI: 10.1016/j.biomaterials.2011.11.042. View

10.

Wu C, Chang J . Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application. Interface Focus. 2013; 2(3):292-306. PMC: 3363021. DOI: 10.1098/rsfs.2011.0121. View

11.

Li X, Shi J, Zhu Y, Shen W, Li H, Liang J . A template route to the preparation of mesoporous amorphous calcium silicate with high in vitro bone-forming bioactivity. J Biomed Mater Res B Appl Biomater. 2007; 83(2):431-9. DOI: 10.1002/jbm.b.30813. View

12.

Wu C, Luo Y, Cuniberti G, Xiao Y, Gelinsky M . Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability. Acta Biomater. 2011; 7(6):2644-50. DOI: 10.1016/j.actbio.2011.03.009. View

13.

Siriphannon P, Kameshima Y, Yasumori A, Okada K, Hayashi S . Influence of preparation conditions on the microstructure and bioactivity of alpha-CaSiO(3) ceramics: formation of hydroxyapatite in simulated body fluid. J Biomed Mater Res. 2000; 52(1):30-9. DOI: 10.1002/1097-4636(200010)52:1<30::aid-jbm5>3.0.co;2-z. View

14.

Wu C, Zhou Y, Chang J, Xiao Y . Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomater. 2013; 9(11):9159-68. DOI: 10.1016/j.actbio.2013.06.026. View

15.

Wu C, Fan W, Chang J . Functional mesoporous bioactive glass nanospheres: synthesis, high loading efficiency, controllable delivery of doxorubicin and inhibitory effect on bone cancer cells. J Mater Chem B. 2020; 1(21):2710-2718. DOI: 10.1039/c3tb20275e. View

16.

Dorozhkin S, Ajaal T . Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings. Proc Inst Mech Eng H. 2009; 223(4):459-70. DOI: 10.1243/09544119JEIM513. View

17.

Carrodeguas R, De Aza A, De Aza P, Baudin C, Jimenez J, Lopez-Bravo A . Assessment of natural and synthetic wollastonite as source for bioceramics preparation. J Biomed Mater Res A. 2007; 83(2):484-95. DOI: 10.1002/jbm.a.31216. View

18.

Wu C, Ramaswamy Y, Kwik D, Zreiqat H . The effect of strontium incorporation into CaSiO3 ceramics on their physical and biological properties. Biomaterials. 2007; 28(21):3171-81. DOI: 10.1016/j.biomaterials.2007.04.002. View

19.

Deligianni D, Katsala N, Koutsoukos P, Missirlis Y . Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials. 2000; 22(1):87-96. DOI: 10.1016/s0142-9612(00)00174-5. View

20.

Martinez-Vazquez F, Perera F, Miranda P, Pajares A, Guiberteau F . Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration. Acta Biomater. 2010; 6(11):4361-8. DOI: 10.1016/j.actbio.2010.05.024. View