Dexamethasone Altered Steroidogenesis and Changed Redox Status of Granulosa Cells

Overview

Journal Endocrine

Specialty Endocrinology

Date 2014 Apr 12

PMID 24723257

Citations 7

Authors

Xiao-Hua Yuan

Bai-Qing Yang

Ying Hu

Yang-Yang Fan

Li-Xia Zhang

Jia-Chen Zhou

Ya-Qin Wang

Cai-Ling Lu

Xu Ma

Affiliations

Soon will be listed here.

Abstract

Glucocorticoids have been widely used in clinical application for anti-inflammatory and immunosuppressive function. Previous study reported that glucocorticoids adversely affect the reproductive system and can directly act on ovary. Here, we found that progesterone production induced by dexamethasone requiring activation of caspase-3 which may mediate differentiation and apoptosis of granulosa cells. Further study displayed that cellular glutathione level was increased and reactive oxygen species was decreased accompanied with unchanged mitochondrial membrane potential which may contribute to the maintenance of steroidogenesis in granulosa cells treated with dexamethasone. Dexamethasone also augmented the level of anti-Müllerian hormone secreted by preovulatory granulosa cells which indicated that dexamethasone may promote preantral follicles development.

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