Multidisciplinary Therapy for Patients with Locally Oligo-recurrent Pelvic Malignancies

Overview

Journal J Cancer Res Clin Oncol

Specialty Oncology

Date 2014 Apr 11

PMID 24718720

Citations 1

Authors

Claudio V Sole

Felipe A Calvo

Pedro Alvarez de Sierra

Rafael Herranz

Luis Gonzalez-Bayon

Jose Luis Garcia-Sabrido

Affiliations

Soon will be listed here.

Abstract

Purpose: To analyze prognostic factors and long-term outcomes in patients with locally recurrent pelvic cancer (LRPC) treated with a multidisciplinary approach.

Methods And Materials: From January 1995 to December 2011, 81 patients [rectal (47 %); gynecologic (39 %); retroperitoneal sarcoma (14 %)] underwent extended surgery [multiorgan (58 %), bone (35 %), vascular (9 %), soft tissue (63 %)] and intraoperative electron beam radiation therapy (IOERT) to treat recurrent tumors in the pelvic region. Thirty-five patients (43 %) received external beam radiotherapy (EBRT). Survival was estimated using the Kaplan-Meier method, and risk factors were identified using univariate and multivariate analysis.

Results: Median follow-up was 39 months (6-189 months); the 1- 3- and 5-year rates of locoregional control (LRC) were 83, 53, and 41 %, respectively. Univariate Cox proportional hazard analysis revealed worse LRC in patients who did not receive integrated EBRT as rescue treatment of pelvic recurrence (p = 0.003) or underwent non-radical resection (p = 0.01). In the multivariate analysis EBRT, non-radical resection, and tumor fragmentation retained significance (p = 0.002, p = 0.004, and p = 0.05, respectively).

Conclusions: Radical resection, absence of tumor fragmentation and addition of EBRT for rescue are associated with improved LRC in patients with LRPC. Our results suggest that this group can benefit from EBRT combined with extended surgical resection and IOERT.

Citing Articles

Bibliometrics of intraoperative radiotherapy: analysis of technology, practice and publication tendencies.

Sole C, Calvo F, Ferrer C, Pascau J, Marsiglia H Strahlenther Onkol. 2014; 190(12):1111-6.

PMID: 24928250 DOI: 10.1007/s00066-014-0695-0.

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