Correlation Between Expression of Cell Adhesion Molecules CD₄₄ V6 and E-cadherin and Lymphatic Metastasis in Non- Small Cell Lung Cancer

Overview

Journal Asian Pac J Cancer Prev

Specialty Oncology

Date 2014 Apr 11

PMID 24716905

Citations 9

Authors

Chong-Yu Su

Yun-Song Li

Yi Han

Shi-Jie Zhou

Zhi-Dong Liu

Affiliations

Soon will be listed here.

Abstract

Objective: To explore the relationship between expressions of cell adhesion molecules CD44 v6 and E-cadherin (E-cad) and lymphatic metastasis in non-small cell lung cancer (NSCLC).

Materials And Methods: Eighty- seven tissue samples obtained from patients with primary NSCLC were collected in our hospital from Dec., 2007 to Dec., 2012, and the expressions of CD44 v6 and E-cad gene proteins in these samples were detected by immunohistochemical method.

Results: In the tissue without lymphatic metastasis, the positive expression rate of CD44 v6 was significantly lower, whereas the normal expression rate of E-cad was notably higher than that with lymphatic metastasis (55.6% vs. 78.4%, 47.2% vs. 21.6%), and both differences had statistical significance (P<0.05). Besides, CD44 v6 and E-cad expressions had a significant correlation in the NSCLC tissue with lymphatic metastasis (P<0.05).

Conclusions: The positive expression of CD44 v6 and abnormal expression of E-cad may play a very important role in promoting lymphatic metastasis of NSCLC, with synergistic effect. Hence, detection of CD44 v6 and E-cad expressions is conductive to judging the lymphatic metastasis in NSCLC.

Citing Articles

RNA-binding protein CELF6 modulates transcription and splicing levels of genes associated with tumorigenesis in lung cancer A549 cells.

Ma H, Liu G, Yu B, Wang J, Qi Y, Kou Y PeerJ. 2022; 10:e13800.

PMID: 35910766 PMC: 9336609. DOI: 10.7717/peerj.13800.

Clinical significance of epithelial-mesenchymal transition-related molecules in lung adenocarcinoma.

Zhang Y, Wang L, Gao J, Li L, Jiang P, Lv X Curr Oncol. 2019; 26(2):e121-e127.

PMID: 31043817 PMC: 6476438. DOI: 10.3747/co.26.4471.

Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma.

Halpern A, Kohtz P, Rove J, Ao L, Meng X, Fullerton D Mol Cell Biochem. 2019; 456(1-2):145-156.

PMID: 30684134 DOI: 10.1007/s11010-019-03500-3.

C3G dynamically associates with nuclear speckles and regulates mRNA splicing.

Shakyawar D, Muralikrishna B, Radha V Mol Biol Cell. 2018; 29(9):1111-1124.

PMID: 29496966 PMC: 5921577. DOI: 10.1091/mbc.E17-07-0442.

Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells.

Li L, Qi L, Liang Z, Song W, Liu Y, Wang Y Int J Mol Med. 2015; 36(1):113-22.

PMID: 26005723 PMC: 4494581. DOI: 10.3892/ijmm.2015.2222.