Interferon-stimulated Genes: Roles in Viral Pathogenesis

Overview

Journal Curr Opin Virol

Publisher Elsevier

Specialty Microbiology

Date 2014 Apr 10

PMID 24713352

Citations 171

Authors

John W Schoggins

Affiliations

Soon will be listed here.

Abstract

Interferon-stimulated genes (ISGs) are critical for controlling virus infections. As new antiviral ISGs continue to be identified and characterized, their roles in viral pathogenesis are also being explored in more detail. Our current understanding of how ISGs impact viral pathogenesis comes largely from studies in knockout mice, with isolated examples from human clinical data. This review outlines recent developments on the contributions of various ISGs to viral disease outcomes in vivo.

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