The Effect of Early Environmental Manipulation on Locomotor Sensitivity and Methamphetamine Conditioned Place Preference Reward

Overview

Journal Behav Brain Res

Specialties Neurology
Psychology
Social Sciences

Date 2014 Apr 10

PMID 24713150

Citations 14

Authors

E Hensleigh

L M Pritchard

Affiliations

Soon will be listed here.

Abstract

Early life stress leads to several effects on neurological development, affecting health and well-being later in life. Instances of child abuse and neglect are associated with higher rates of depression, risk taking behavior, and an increased risk of drug abuse later in life. This study used repeated neonatal separation of rat pups as a model of early life stress. Rat pups were either handled and weighed as controls or separated for 180 min per day during postnatal days 2-8. In adulthood, male and female rats were tested for methamphetamine conditioned place preference reward and methamphetamine induced locomotor activity. Tissue samples were collected and mRNA was quantified for the norepinephrine transporter in the prefrontal cortex and the dopamine transporter in the nucleus accumbens. Results indicated rats given methamphetamine formed a conditioned place preference, but there was no effect of early separation or sex. Separated males showed heightened methamphetamine-induced locomotor activity, but there was no effect of early separation for females. Overall females were more active than males in response to both saline and methamphetamine. No differences in mRNA levels were observed across any conditions. These results suggest early neonatal separation affects methamphetamine-induced locomotor activity in a sex-dependent manner but has no effects on methamphetamine conditioned place preference.

Citing Articles

Modeling methamphetamine use disorder in mammals: Sex differences in behavioral, biochemical, and transcriptional consequences.

Daiwile A, Cadet J Adv Pharmacol. 2024; 99:145-168.

PMID: 38467480 PMC: 11474929. DOI: 10.1016/bs.apha.2023.08.002.

Effects of adolescent methylphenidate administration on methamphetamine conditioned place preference in an animal model of attention-deficit/hyperactivity disorder: Examination of potential sex differences.

Yates J, Broderick M, Berling K, Gieske M, Osborn E, Nelson M Drug Alcohol Depend. 2023; 252:110970.

PMID: 37748422 PMC: 10615784. DOI: 10.1016/j.drugalcdep.2023.110970.

Early-life adversity increases anxiety-like behavior and modifies synaptic protein expression in a region-specific manner.

Hamdan J, Sierra-Fonseca J, Flores R, Saucedo Jr S, Miranda-Arango M, ODell L Front Behav Neurosci. 2022; 16:1008556.

PMID: 36338879 PMC: 9626971. DOI: 10.3389/fnbeh.2022.1008556.

Oxytocin as an adolescent treatment for methamphetamine addiction after early life stress in male and female rats.

Baracz S, Robinson K, Wright A, Turner A, McGregor I, Cornish J Neuropsychopharmacology. 2022; 47(8):1561-1573.

PMID: 35581382 PMC: 9206013. DOI: 10.1038/s41386-022-01336-y.

Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts.

Daiwile A, Jayanthi S, Cadet J Neurosci Biobehav Rev. 2022; 137:104674.

PMID: 35452744 PMC: 9119944. DOI: 10.1016/j.neubiorev.2022.104674.

References

Muhammad A, Kolb B . Maternal separation altered behavior and neuronal spine density without influencing amphetamine sensitization. Behav Brain Res. 2011; 223(1):7-16. DOI: 10.1016/j.bbr.2011.04.015. View

Plotsky P, Thrivikraman K, Nemeroff C, Caldji C, Sharma S, Meaney M . Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology. 2005; 30(12):2192-204. DOI: 10.1038/sj.npp.1300769. View

Weiss I, Domeney A, Heidbreder C, Moreau J, Feldon J . Early social isolation, but not maternal separation, affects behavioral sensitization to amphetamine in male and female adult rats. Pharmacol Biochem Behav. 2001; 70(2-3):397-409. DOI: 10.1016/s0091-3057(01)00626-8. View

Moffett M, Vicentic A, Kozel M, Plotsky P, Francis D, Kuhar M . Maternal separation alters drug intake patterns in adulthood in rats. Biochem Pharmacol. 2006; 73(3):321-30. PMC: 2692348. DOI: 10.1016/j.bcp.2006.08.003. View

Yang P, Yi-Kung Huang E, Fu Y, Ho T, Tao P . Post-treatment of dextromethorphan on methamphetamine-induced drug-seeking and behavioral sensitization in rats. Synapse. 2012; 66(10):858-69. DOI: 10.1002/syn.21576. View

Tilley M, ONeill B, Han D, Gu H . Cocaine does not produce reward in absence of dopamine transporter inhibition. Neuroreport. 2008; 20(1):9-12. PMC: 4277863. DOI: 10.1097/WNR.0b013e32831b9ce4. View

Boulay D, Depoortere R, Perrault G, Borrelli E, Sanger D . Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists. Neuropharmacology. 1999; 38(9):1389-96. DOI: 10.1016/s0028-3908(99)00064-7. View

Zhang L, Levine S, Dent G, Zhan Y, Xing G, Okimoto D . Maternal deprivation increases cell death in the infant rat brain. Brain Res Dev Brain Res. 2002; 133(1):1-11. DOI: 10.1016/s0926-6410(01)00118-5. View

Krasnova I, Justinova Z, Ladenheim B, Jayanthi S, McCoy M, Barnes C . Methamphetamine self-administration is associated with persistent biochemical alterations in striatal and cortical dopaminergic terminals in the rat. PLoS One. 2010; 5(1):e8790. PMC: 2808335. DOI: 10.1371/journal.pone.0008790. View

10.

Pritchard L, Hensleigh E, Lynch S . Altered locomotor and stereotyped responses to acute methamphetamine in adolescent, maternally separated rats. Psychopharmacology (Berl). 2012; 223(1):27-35. PMC: 3398239. DOI: 10.1007/s00213-012-2679-z. View

11.

Koob G, Le Moal M . Drug abuse: hedonic homeostatic dysregulation. Science. 1997; 278(5335):52-8. DOI: 10.1126/science.278.5335.52. View

12.

Kikusui T, Faccidomo S, Miczek K . Repeated maternal separation: differences in cocaine-induced behavioral sensitization in adult male and female mice. Psychopharmacology (Berl). 2004; 178(2-3):202-10. DOI: 10.1007/s00213-004-1989-1. View

13.

Dimatelis J, Russell V, Stein D, Daniels W . Effects of maternal separation and methamphetamine exposure on protein expression in the nucleus accumbens shell and core. Metab Brain Dis. 2012; 27(3):363-75. DOI: 10.1007/s11011-012-9295-9. View

14.

Levine S . Primary social relationships influence the development of the hypothalamic--pituitary--adrenal axis in the rat. Physiol Behav. 2001; 73(3):255-60. DOI: 10.1016/s0031-9384(01)00496-6. View

15.

Matthews K, Robbins T, Everitt B, Caine S . Repeated neonatal maternal separation alters intravenous cocaine self-administration in adult rats. Psychopharmacology (Berl). 1999; 141(2):123-34. DOI: 10.1007/s002130050816. View

16.

Brake W, Zhang T, Diorio J, Meaney M, Gratton A . Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats. Eur J Neurosci. 2004; 19(7):1863-74. DOI: 10.1111/j.1460-9568.2004.03286.x. View

17.

Silvagni A, Barros V, Mura C, Antonelli M, Carboni E . Prenatal restraint stress differentially modifies basal and stimulated dopamine and noradrenaline release in the nucleus accumbens shell: an 'in vivo' microdialysis study in adolescent and young adult rats. Eur J Neurosci. 2008; 28(4):744-58. DOI: 10.1111/j.1460-9568.2008.06364.x. View

18.

Weaver S, Diorio J, Meaney M . Maternal separation leads to persistent reductions in pain sensitivity in female rats. J Pain. 2007; 8(12):962-9. DOI: 10.1016/j.jpain.2007.07.001. View

19.

Douglass J, McKinzie A, Couceyro P . PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci. 1995; 15(3 Pt 2):2471-81. PMC: 6578117. View

20.

Kalivas P, Stewart J . Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Brain Res Rev. 1991; 16(3):223-44. DOI: 10.1016/0165-0173(91)90007-u. View