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NMR-based Approaches for the Identification and Optimization of Inhibitors of Protein-protein Interactions

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Journal Chem Rev
Specialty Chemistry
Date 2014 Apr 10
PMID 24712885
Citations 45
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References
1.
Jahnke W, Rudisser S, Zurini M . Spin label enhanced NMR screening. J Am Chem Soc. 2001; 123(13):3149-50. DOI: 10.1021/ja005836g. View

2.
Becattini B, Sareth S, Zhai D, Crowell K, Leone M, Reed J . Targeting apoptosis via chemical design: inhibition of bid-induced cell death by small organic molecules. Chem Biol. 2004; 11(8):1107-17. DOI: 10.1016/j.chembiol.2004.05.022. View

3.
McGovern S, Helfand B, Feng B, Shoichet B . A specific mechanism of nonspecific inhibition. J Med Chem. 2003; 46(20):4265-72. DOI: 10.1021/jm030266r. View

4.
Dalvit C, Fasolini M, Flocco M, Knapp S, Pevarello P, Veronesi M . NMR-Based screening with competition water-ligand observed via gradient spectroscopy experiments: detection of high-affinity ligands. J Med Chem. 2002; 45(12):2610-4. DOI: 10.1021/jm011122k. View

5.
Ferguson F, Fedorov O, Chaikuad A, Philpott M, Muniz J, Felletar I . Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. J Med Chem. 2013; 56(24):10183-7. PMC: 3905694. DOI: 10.1021/jm401582c. View