The Anti-apoptotic Role of Neuroglobin

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2014 Apr 9

PMID 24710547

Citations 15

Authors

Thomas Brittain

Affiliations

Soon will be listed here.

Abstract

The small heme-protein neuroglobin is expressed at high concentrations in certain brain neurons and in the rod cells of the retina. This paper reviews the many studies which have recently identified a protective role for neuroglobin, in a wide range of situations involving apoptotic cell death. The origins of this protective mechanism are discussed in terms of both experimental results and computational modeling of the intrinsic pathway of apoptosis, which shows that neuroglobin can intervene in this process by a reaction with released mitochondrial cytochrome c. An integrated model, based on the various molecular actions of both neuroglobin and cytochrome c, is developed, which accounts for the cellular distribution of neuroglobin.

Citing Articles

Hydrogen peroxide induces heme degradation and protein aggregation in human neuroglobin: roles of the disulfide bridge and hydrogen-bonding in the distal heme cavity.

Di Rocco G, Bernini F, Battistuzzi G, Ranieri A, Bortolotti C, Borsari M FEBS J. 2022; 290(1):148-161.

PMID: 35866372 PMC: 10087938. DOI: 10.1111/febs.16581.

Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes.

Abuhamdah S, Saleem T, Elsadek B, Ashraf O, Hamdan A, El-Khateeb E Int J Gen Med. 2022; 15:5795-5805.

PMID: 35783999 PMC: 9242088. DOI: 10.2147/IJGM.S364736.

Planet of the AAVs: The Spinal Cord Injury Episode.

Stepankova K, Jendelova P, Machova Urdzikova L Biomedicines. 2021; 9(6).

PMID: 34071245 PMC: 8228984. DOI: 10.3390/biomedicines9060613.

Neuroglobin Expression Models as a Tool to Study Its Function.

Luyckx E, Van Acker Z, Ponsaerts P, Dewilde S Oxid Med Cell Longev. 2019; 2019:5728129.

PMID: 31320982 PMC: 6607734. DOI: 10.1155/2019/5728129.

Neuroglobin Expression in the Brain: a Story of Tissue Homeostasis Preservation.

Van Acker Z, Luyckx E, Dewilde S Mol Neurobiol. 2018; 56(3):2101-2122.

PMID: 29992530 DOI: 10.1007/s12035-018-1212-8.

References

Jin K, Mao X, Xie L, Greenberg D . Neuroglobin expression in human arteriovenous malformation and intracerebral hemorrhage. Acta Neurochir Suppl. 2011; 111:315-9. PMC: 3234111. DOI: 10.1007/978-3-7091-0693-8_52. View

Chen X, Lin W, Lin J, Wu C, Zhang L, Huang Z . The protective effects of the lentivirus-mediated neuroglobin gene transfer on spinal cord injury in rabbits. Spinal Cord. 2011; 50(6):467-71. DOI: 10.1038/sc.2011.138. View

Dong Y, Zhao R, Chen X, Yu A . 14-3-3gamma and neuroglobin are new intrinsic protective factors for cerebral ischemia. Mol Neurobiol. 2010; 41(2-3):218-31. DOI: 10.1007/s12035-010-8142-4. View

Gillies G, McArthur S . Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines. Pharmacol Rev. 2010; 62(2):155-98. PMC: 2879914. DOI: 10.1124/pr.109.002071. View

Emara M, Salloum N, Allalunis-Turner J . Expression and hypoxic up-regulation of neuroglobin in human glioblastoma cells. Mol Oncol. 2009; 3(1):45-53. PMC: 5527870. DOI: 10.1016/j.molonc.2008.11.002. View

Wang X, Liu J, Zhu H, Tejima E, Tsuji K, Murata Y . Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke. 2008; 39(6):1869-74. PMC: 2727360. DOI: 10.1161/STROKEAHA.107.506022. View

Li R, Pouranfar F, Lee S, Morris M, Wang Y, Gozal D . Neuroglobin protects PC12 cells against beta-amyloid-induced cell injury. Neurobiol Aging. 2007; 29(12):1815-22. PMC: 2586918. DOI: 10.1016/j.neurobiolaging.2007.05.001. View

Ye S, Zhou X, Lai X, Zheng L, Chen X . Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin. 2009; 30(7):913-8. PMC: 4006654. DOI: 10.1038/aps.2009.70. View

Rajendram R, Rao N . Neuroglobin in normal retina and retina from eyes with advanced glaucoma. Br J Ophthalmol. 2006; 91(5):663-6. PMC: 1954743. DOI: 10.1136/bjo.2006.093930. View

10.

Li R, Morris M, Lee S, Pouranfar F, Wang Y, Gozal D . Neuroglobin protects PC12 cells against oxidative stress. Brain Res. 2007; 1190:159-66. PMC: 2323248. DOI: 10.1016/j.brainres.2007.11.022. View

11.

Beltran-Parrazal L, Acuna D, Ngan A, Kim E, Ngan A, Kawakami K . Neuroglobin, cytoglobin, and transcriptional profiling of hypoxia-related genes in the rat cerebellum after prenatal chronic very mild carbon monoxide exposure (25 ppm). Brain Res. 2010; 1330:61-71. DOI: 10.1016/j.brainres.2010.03.005. View

12.

Khan A, Sun Y, Jin K, Mao X, Chen S, Ellerby L . A neuroglobin-overexpressing transgenic mouse. Gene. 2007; 398(1-2):172-6. PMC: 2098872. DOI: 10.1016/j.gene.2007.02.044. View

13.

Li W, Wu Y, Ren C, Lu Y, Gao Y, Zheng X . The activity of recombinant human neuroglobin as an antioxidant and free radical scavenger. Proteins. 2010; 79(1):115-25. DOI: 10.1002/prot.22863. View

14.

Pesce A, de Sanctis D, Nardini M, Dewilde S, Moens L, Hankeln T . Reversible hexa- to penta-coordination of the heme Fe atom modulates ligand binding properties of neuroglobin and cytoglobin. IUBMB Life. 2005; 56(11-12):657-64. DOI: 10.1080/15216540500078830. View

15.

Fago A, Mathews A, Brittain T . A role for neuroglobin: resetting the trigger level for apoptosis in neuronal and retinal cells. IUBMB Life. 2008; 60(6):398-401. DOI: 10.1002/iub.35. View

16.

Greenberg D, Jin K, Khan A . Neuroglobin: an endogenous neuroprotectant. Curr Opin Pharmacol. 2007; 8(1):20-4. PMC: 2387246. DOI: 10.1016/j.coph.2007.09.003. View

17.

Lin Y, Fang L, Xue X, Murong S, Wang N, Wu Z . Association between Ngb polymorphisms and ischemic stroke in the Southern Chinese Han population. BMC Med Genet. 2008; 9:110. PMC: 2639551. DOI: 10.1186/1471-2350-9-110. View

18.

Kang Y, Kim P, Choi B, Chung H, Ha K, Kwon Y . Regulation of programmed cell death in neuronal cells by nitric oxide. In Vivo. 2004; 18(3):367-76. View

19.

Fago A, Mathews A, Moens L, Dewilde S, Brittain T . The reaction of neuroglobin with potential redox protein partners cytochrome b5 and cytochrome c. FEBS Lett. 2006; 580(20):4884-8. DOI: 10.1016/j.febslet.2006.08.003. View

20.

Borutaite V, Brown G . Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state. J Biol Chem. 2007; 282(43):31124-30. DOI: 10.1074/jbc.M700322200. View