Cohesin in Oocytes-tough Enough for Mammalian Meiosis?

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2014 Apr 9

PMID 24710099

Citations 7

Authors

Ekaterina Revenkova

Caroline Adelfalk

Rolf Jessberger

Affiliations

Soon will be listed here.

Abstract

Sister chromatid cohesion is essential for cell division. During meiosis, it is also required for proper synapsis of pairs of sister chromatids and for chiasma formation and maintenance. Since mammalian oocytes remain arrested in late prophase for a very long period-up to five decades in humans-the preservation of cohesion throughout this period is a formidable challenge. Mouse models with cohesin deficiencies and aging wild-type mice showed that this challenge is not fully met: cohesion weakens and deteriorates with increasing age. These recent findings have highly significant implications for our comprehension of the genesis of aneuploidies.

Citing Articles

Effects of post-ovulatory aging on centromeric cohesin protection in murine MII oocytes.

Shimoi G, Wakabayashi R, Ishikawa R, Kameyama Y Reprod Med Biol. 2022; 21(1).

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TRF1 Depletion Reveals Mutual Regulation Between Telomeres, Kinetochores, and Inner Centromeres in Mouse Oocytes.

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The ectopic expression of meiCT genes promotes meiomitosis and may facilitate carcinogenesis.

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Destabilization of spindle assembly checkpoint causes aneuploidy during meiosis II in murine post-ovulatory aged oocytes.

Shimoi G, Tomita M, Kataoka M, Kameyama Y J Reprod Dev. 2018; 65(1):57-66.

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A comparison of the multiple oocyte maturation gene expression patterns between the newborn and adult mouse ovary.

Bahmanpour S, Khozani T, Fard N, Jaberipour M, Hosseini A, Esmaeilpour T Iran J Reprod Med. 2014; 11(10):815-22.

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