Parental Obesity and Risk of Autism Spectrum Disorder

Overview

Journal Pediatrics

Specialty Pediatrics

Date 2014 Apr 9

PMID 24709932

Citations 55

Authors

Pal Suren

Nina Gunnes

Christine Roth

Michaeline Bresnahan

Mady Hornig

Deborah Hirtz

Kari Kveim Lie

W Ian Lipkin

Per Magnus

Ted Reichborn-Kjennerud

Synnve Schjolberg

Ezra Susser

Anne-Siri Oyen

George Davey Smith

Camilla Stoltenberg

Affiliations

Soon will be listed here.

Abstract

Objectives: The objective of the study was to investigate the associations among maternal prepregnancy BMI, paternal BMI, and the risk of autism spectrum disorders (ASDs) in children.

Methods: The study sample of 92 909 children was derived from the population-based, prospective Norwegian Mother and Child Cohort Study. The age range was 4.0 through 13.1 (mean 7.4) years. Relative risks of ASDs were estimated by odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models.

Results: At the end of follow-up on December 31, 2012, 419 children in the study sample had been diagnosed with ASDs: 162 with autistic disorder, 103 with Asperger disorder, and 154 with pervasive developmental disorder not otherwise specified. Maternal obesity (BMI ≥30) was only weakly associated with ASD risk, whereas paternal obesity was associated with an increased risk of autistic disorder and Asperger disorder. The risk of autistic disorder was 0.27% (25 of 9267) in children of obese fathers and 0.14% (59 of 41 603) in children of fathers with normal weight (BMI <25), generating an adjusted OR of 1.73 (95% CI: 1.07-2.82). For Asperger disorder, analyses were limited to children aged ≥7 years (n = 50 116). The risk was 0.38% (18 of 4761) in children of obese fathers and 0.18% (42 of 22 736) in children of normal-weight fathers, and the adjusted OR was 2.01 (95% CI: 1.13-3.57). No associations were found for pervasive developmental disorder not otherwise specified.

Conclusions: Paternal obesity is an independent risk factor for ASDs in children. The associations should be investigated further in genetic and epigenetic studies.

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