Efficacy of Ginseng Adventitious Root Extract on Hyperglycemia in Streptozotocin-induced Diabetic Rats

Overview

Journal J Ethnopharmacol

Date 2014 Apr 9

PMID 24709314

Citations 11

Authors

Hosakatte Niranjana Murthy

Vijayalaxmi S Dandin

Eun Jung Lee

Kee Yoeup Paek

Affiliations

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Abstract

Ethnopharmacological Relevance: Ginseng has various bioactive effects on human health including its potential activity of improving the glucose homeostasis and insulin sensitivity.

Materials And Methods: Tissue culture raised mountain ginseng adventitious root (TCMGARs) extract enriched with ginsenosides was used as experimental material. Streptozotocin-induced diabetic 'Sprague Dawley' male rats were used as experimental systems and were fed with Tissue culture raised mountain ginseng adventitious root extract. Field cultivated Korean ginseng root extract fed rats were used as positive control and several indices such as body weight, blood glucose level and other serological indicators were tested.

Results: Chemical profile showed TCMGARs were rich in varied ginsenosides especially Rb1, Rb2, Rc, Rd, Rg3, and Rh2 when compared to field cultivated Korean ginseng. TCMGARs extract at dosage levels of 250 and 500 mg/kg body weight significantly lowered the blood glucose, total cholesterol and triglyceride content in streptozotocin-induced diabetic rats.

Conclusion: The data of in vivo experiments on anti-glycemic effects of TCMGARs proves their efficacy and also their use as dietary supplement.

Citing Articles

Comparative Assessment of In Vitro Xanthine Oxidase and α-Glucosidase Inhibitory Activities of Cultured Cambial Meristematic Cells, Adventitious Roots, and Field-Cultivated Ginseng.

Zhang T, Liu L, Chen Q, Wang Y, Gao X, Ma X Nutrients. 2024; 16(3).

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Phytochemicals and their Potential Mechanisms against Insulin Resistance.

Wal P Curr Diabetes Rev. 2023; 20(7):e081123223322.

PMID: 37946350 DOI: 10.2174/0115733998262924231020083353.

Study on hypoglycemic effects of irradiated ginseng adventitious roots.

Zhang L, Qi X, Lu X, Cui C, Gao X Food Chem X. 2022; 13:100234.

PMID: 35499036 PMC: 9039912. DOI: 10.1016/j.fochx.2022.100234.

Review of Ginseng Anti-Diabetic Studies.

Chen W, Balan P, Popovich D Molecules. 2019; 24(24).

PMID: 31835292 PMC: 6943541. DOI: 10.3390/molecules24244501.

Effects of Huanglian-Renshen-Decoction, a Fixed Mixture of Traditional Chinese Medicine, on the Improvement of Glucose Metabolism by Maintenance of Pancreatic Cell Identity in db/db Mice.

Yuan F, Wang D, Ma L, Qin X, Gong J, Hu M Evid Based Complement Alternat Med. 2019; 2019:1232913.

PMID: 31015847 PMC: 6444265. DOI: 10.1155/2019/1232913.