Implications of Salivary Protein Binding to Commensal and Pathogenic Bacteria

Overview

Journal J Oral Biosci

Specialty Dentistry

Date 2014 Apr 8

PMID 24707190

Citations 8

Authors

Seok-Mo Heo

Stefan Ruhl

Frank A Scannapieco

Affiliations

Soon will be listed here.

Abstract

An important function of salivary proteins is to interact with microorganisms that enter the oral cavity. For some microbes, these interactions promote microbial colonization. For others, these interactions are deleterious and result in the elimination of the microbe from the mouth, This paper reviews recent studies of the interaction of salivary proteins with two model bacteria; the commensal species , and the facultative pathogen . These organisms selectively interact with a variety of salivary proteins to influence important functions such as bacterial adhesion to surfaces, evasion of host defense, bacterial nutrition and metabolism and gene expression.

Citing Articles

Protein Deposition on Sport Mouthguards and the Effectiveness of Two Different Cleaning Protocols.

van Vliet K, van Splunter A, de Lange J, Lobbezoo F, Brand H J Clin Med. 2024; 13(11).

PMID: 38892734 PMC: 11172541. DOI: 10.3390/jcm13113023.

Host-derived protease promotes aggregation of by cleaving the surface protein SasG.

Crosby H, Keim K, Kwiecinski J, Langouet-Astrie C, Oshima K, LaRiviere W mBio. 2024; 15(4):e0348323.

PMID: 38511930 PMC: 11005337. DOI: 10.1128/mbio.03483-23.

Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals.

Ghosh S, Ahearn C, Isabella C, Marando V, Dodge G, Bartlett H Proc Natl Acad Sci U S A. 2023; 120(22):e2216304120.

PMID: 37216558 PMC: 10235990. DOI: 10.1073/pnas.2216304120.

biofilm formation on different titanium surface topographies.

Mouhat M, Moorehead R, Murdoch C Biomater Investig Dent. 2020; 7(1):146-157.

PMID: 33134957 PMC: 7580804. DOI: 10.1080/26415275.2020.1829489.

Effect of mechanically stimulated saliva on initial human dental biofilm formation.

Inui T, Palmer Jr R, Shah N, Li W, Cisar J, Wu C Sci Rep. 2019; 9(1):11805.

PMID: 31413280 PMC: 6694102. DOI: 10.1038/s41598-019-48211-3.

References

Persson G, Samuelsson E, Lindahl C, Renvert S . Mechanical non-surgical treatment of peri-implantitis: a single-blinded randomized longitudinal clinical study. II. Microbiological results. J Clin Periodontol. 2010; 37(6):563-73. DOI: 10.1111/j.1600-051X.2010.01561.x. View

Rundegren J, Ericson T . Effect of calcium on reactions between a salivary agglutinin and a serotype c strain of Streptococcus mutans. J Oral Pathol. 1981; 10(4):269-75. DOI: 10.1111/j.1600-0714.1981.tb01273.x. View

Senpuku H, Sogame A, Inoshita E, Tsuha Y, Miyazaki H, Hanada N . Systemic diseases in association with microbial species in oral biofilm from elderly requiring care. Gerontology. 2003; 49(5):301-9. DOI: 10.1159/000071711. View

Scannapieco F, Bergey E, Reddy M, LeVine M . Characterization of salivary alpha-amylase binding to Streptococcus sanguis. Infect Immun. 1989; 57(9):2853-63. PMC: 313538. DOI: 10.1128/iai.57.9.2853-2863.1989. View

Nikitkova A, Haase E, Scannapieco F . Taking the starch out of oral biofilm formation: molecular basis and functional significance of salivary α-amylase binding to oral streptococci. Appl Environ Microbiol. 2012; 79(2):416-23. PMC: 3553756. DOI: 10.1128/AEM.02581-12. View

Kukita K, Kawada-Matsuo M, Oho T, Nagatomo M, Oogai Y, Hashimoto M . Staphylococcus aureus SasA is responsible for binding to the salivary agglutinin gp340, derived from human saliva. Infect Immun. 2013; 81(6):1870-9. PMC: 3676022. DOI: 10.1128/IAI.00011-13. View

Bensing B, Sullam P . An accessory sec locus of Streptococcus gordonii is required for export of the surface protein GspB and for normal levels of binding to human platelets. Mol Microbiol. 2002; 44(4):1081-94. DOI: 10.1046/j.1365-2958.2002.02949.x. View

Kroes I, Lepp P, Relman D . Bacterial diversity within the human subgingival crevice. Proc Natl Acad Sci U S A. 1999; 96(25):14547-52. PMC: 24473. DOI: 10.1073/pnas.96.25.14547. View

Douglas C . The binding of human salivary alpha-amylase by oral strains of streptococcal bacteria. Arch Oral Biol. 1983; 28(7):567-73. DOI: 10.1016/0003-9969(83)90003-1. View

10.

Ligtenberg A, Veerman E, Nieuw Amerongen A, Mollenhauer J . Salivary agglutinin/glycoprotein-340/DMBT1: a single molecule with variable composition and with different functions in infection, inflammation and cancer. Biol Chem. 2007; 388(12):1275-89. DOI: 10.1515/BC.2007.158. View

11.

Siboo I, Chambers H, Sullam P . Role of SraP, a Serine-Rich Surface Protein of Staphylococcus aureus, in binding to human platelets. Infect Immun. 2005; 73(4):2273-80. PMC: 1087419. DOI: 10.1128/IAI.73.4.2273-2280.2005. View

12.

Jacobson J, Patel B, Asher G, Woolliscroft J, Schaberg D . Oral staphylococcus in older subjects with rheumatoid arthritis. J Am Geriatr Soc. 1997; 45(5):590-3. DOI: 10.1111/j.1532-5415.1997.tb03092.x. View

13.

Shelburne 3rd S, Sumby P, Sitkiewicz I, Granville C, DeLeo F, Musser J . Central role of a bacterial two-component gene regulatory system of previously unknown function in pathogen persistence in human saliva. Proc Natl Acad Sci U S A. 2005; 102(44):16037-42. PMC: 1276065. DOI: 10.1073/pnas.0505839102. View

14.

Perutz M . Electrostatic effects in proteins. Science. 1978; 201(4362):1187-91. DOI: 10.1126/science.694508. View

15.

Sasso E, Silverman G, Mannik M . Human IgM molecules that bind staphylococcal protein A contain VHIII H chains. J Immunol. 1989; 142(8):2778-83. View

16.

Zou Q, Li R . Helicobacter pylori in the oral cavity and gastric mucosa: a meta-analysis. J Oral Pathol Med. 2011; 40(4):317-24. DOI: 10.1111/j.1600-0714.2011.01006.x. View

17.

LeVine M, Reddy M, Tabak L, Loomis R, Bergey E, Jones P . Structural aspects of salivary glycoproteins. J Dent Res. 1987; 66(2):436-41. DOI: 10.1177/00220345870660020901. View

18.

Gorr S . Antimicrobial peptides of the oral cavity. Periodontol 2000. 2009; 51:152-80. DOI: 10.1111/j.1600-0757.2009.00310.x. View

19.

Brack C, Reynolds E . Characterization of a rat salivary sialoglycoprotein complex which agglutinates Streptococcus mutans. Infect Immun. 1987; 55(5):1264-73. PMC: 260500. DOI: 10.1128/iai.55.5.1264-1273.1987. View

20.

Chang J . Structural heterogeneity of 6 M GdmCl-denatured proteins: implications for the mechanism of protein folding. Biochemistry. 2009; 48(40):9340-6. DOI: 10.1021/bi901417f. View