Cell-type-based Model Explaining Coexpression Patterns of Genes in the Brain

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2014 Apr 8

PMID 24706869

Citations 38

Authors

Pascal Grange

Jason W Bohland

Benjamin W Okaty

Ken Sugino

Hemant Bokil

Sacha B Nelson

Lydia Ng

Michael Hawrylycz

Partha P Mitra

Affiliations

Soon will be listed here.

Abstract

Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-type-specific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.

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