Purinergic Neuron-glia Interactions in Sensory Systems

Overview

Journal Pflugers Arch

Specialty Physiology

Date 2014 Apr 8

PMID 24705940

Citations 19

Authors

Christian Lohr

Antje Grosche

Andreas Reichenbach

Daniela Hirnet

Affiliations

Soon will be listed here.

Abstract

The purine adenosine 5'-triphosphate (ATP) and its breakdown products, ADP and adenosine, act as intercellular messenger molecules throughout the nervous system. While ATP contributes to fast synaptic transmission via activation of ionotropic P2X receptors as well as neuromodulation via metabotropic P2Y receptors, ADP and adenosine only stimulate P2Y and P1 receptors, respectively, thereby adjusting neuronal performance. Often glial cells are recipient as well as source for extracellular ATP. Hence, purinergic neuron-glia signalling contributes bidirectionally to information processing in the nervous system, including sensory organs and brain areas computing sensory information. In this review, we summarize recent data of purinergic neuron-glia communication in two sensory systems, the visual and the olfactory systems. In both retina and olfactory bulb, ATP is released by neurons and evokes Ca(2+) transients in glial cells, viz. Müller cells, astrocytes and olfactory ensheathing cells. Glial Ca(2+) signalling, in turn, affects homeostasis of the nervous tissue such as volume regulation and control of blood flow. In addition, 'gliotransmitter' release upon Ca(2+) signalling--evoked by purinoceptor activation--modulates neuronal activity, thus contributing to the processing of sensory information.

Citing Articles

Astrocytic activation increases blood flow in the adult olfactory bulb.

Ogino T, Agetsuma M, Sawada M, Inada H, Nabekura J, Sawamoto K Mol Brain. 2024; 17(1):52.

PMID: 39107815 PMC: 11301997. DOI: 10.1186/s13041-024-01126-1.

A adenosine receptor-driven cAMP signaling in olfactory bulb astrocytes is unaffected in experimental autoimmune encephalomyelitis.

Wendlandt M, Kurten A, Beiersdorfer A, Schubert C, Samad-Yazdtchi K, Sauer J Front Immunol. 2023; 14:1273837.

PMID: 38077336 PMC: 10701430. DOI: 10.3389/fimmu.2023.1273837.

Norepinephrine-Induced Calcium Signaling and Store-Operated Calcium Entry in Olfactory Bulb Astrocytes.

Fischer T, Prey J, Eschholz L, Rotermund N, Lohr C Front Cell Neurosci. 2021; 15:639754.

PMID: 33833669 PMC: 8021869. DOI: 10.3389/fncel.2021.639754.

A Circadian Clock in the Retina Regulates Rod-Cone Gap Junction Coupling and Neuronal Light Responses Activation of Adenosine A Receptors.

Cao J, Ribelayga C, Mangel S Front Cell Neurosci. 2021; 14:605067.

PMID: 33510619 PMC: 7835330. DOI: 10.3389/fncel.2020.605067.

Age-Dependent Heterogeneity of Murine Olfactory Bulb Astrocytes.

Klein M, Lohr C, Droste D Front Aging Neurosci. 2020; 12:172.

PMID: 32581775 PMC: 7296154. DOI: 10.3389/fnagi.2020.00172.

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