The Effects of Spinal, Inhalation, and Total Intravenous Anesthetic Techniques on Ischemia-reperfusion Injury in Arthroscopic Knee Surgery

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2014 Apr 5

PMID 24701585

Citations 5

Authors

Muge Kosucu

Ilker Coskun

Ahmet Eroglu

Dilek Kutanis

Ahmet Mentese

S Caner Karahan

Emre Baki

Servet Kerimoglu

Murat Topbas

Affiliations

Soon will be listed here.

Abstract

Purpose: To compare the effects of different anesthesia techniques on tourniquet-related ischemia-reperfusion by measuring the levels of malondialdehyde (MDA), ischemia-modified albumin (IMA) and neuromuscular side effects.

Methods: Sixty ASAI-II patients undergoing arthroscopic knee surgery were randomised to three groups. In Group S, intrathecal anesthesia was administered using levobupivacaine. Anesthesia was induced and maintained with sevoflurane in Group I and TIVA with propofol in Group T. Blood samples were obtained before the induction of anesthesia (t1), 30 min after tourniquet inflation (t2), immediately before (t3), and 5 min (t4), 15 min (t5), 30 min (t 6), 1 h (t7), 2 h (t8), and 6 h (t9) after tourniquet release.

Results: MDA and IMA levels increased significantly compared with baseline values in Group S at t2-t 9 and t2-t7. MDA levels in Group T and Group I were significantly lower than those in Group S at t2-t8 and t2-t9. IMA levels in Group T were significantly lower than those in Group S at t2-t7. Postoperatively, a temporary 1/5 loss of strength in dorsiflexion of the ankle was observed in 3 patients in Group S and 1 in Group I.

Conclusions: TIVA with propofol can make a positive contribution in tourniquet-related ischemia-reperfusion.

Citing Articles

The Effect of Dexmedetomidine and Levobupivacaine in an Experimental Ischemia Reperfusion Model.

Ibrahim T, Sevgi K, Sibel O, Surhan C, Kaan K, Kubra B In Vivo. 2024; 38(6):2696-2704.

PMID: 39477431 PMC: 11535938. DOI: 10.21873/invivo.13747.

Comparison of the effects of axillary brachial plexus block, inhalation anesthesia, and total intravenous anesthesia on tourniquet-induced ischemia-reperfusion injury in upper extremity surgery.

Kutanis D, Erturk E, Akdogan A, Besir A, Altinbas A, Orem A Ulus Travma Acil Cerrahi Derg. 2024; 30(7):510-517.

PMID: 38967530 PMC: 11331351. DOI: 10.14744/tjtes.2024.63534.

Impact of Dexmedetomidine on Tourniquet-Induced Systemic Effects in Total Knee Arthroplasty under Spinal Anesthesia: a Prospective Randomized, Double-Blinded Study.

Lee C, Lee C, So C, Lee J, Choi I, Ma X Biomed Res Int. 2020; 2020:4208597.

PMID: 33083465 PMC: 7559225. DOI: 10.1155/2020/4208597.

Protective Effects of Rocuronium Bromide on Ischemia-Reperfusion Injury in Skeletal Muscle Induced by Tourniquet in Patients Undergoing Elective Unilateral Total Knee Arthroplasty: A Prospective, Double Blind, Randomized, Controlled Study.

Chen H, Wei J, Wang Y, Zhou K, He Y, Liu H Drug Des Devel Ther. 2020; 14:3373-3384.

PMID: 32884241 PMC: 7443440. DOI: 10.2147/DDDT.S252546.

MicroRNA-153-3p increases autophagy in sevoflurane-preconditioned mice to protect against ischaemic/reperfusion injury after knee arthroplasty.

Qiu S, Liu B, Mo Y, Wang X, Zhong L, Han X J Cell Mol Med. 2020; 24(9):5330-5340.

PMID: 32239627 PMC: 7205820. DOI: 10.1111/jcmm.15188.

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