Vitamin E, γ-tocopherol, Diminishes Ex Vivo Basophil Response to Dust Mite Allergen

Overview

Journal Allergy

Specialty Allergy & Immunology

Date 2014 Apr 5

PMID 24697338

Citations 8

Authors

K Mills

J Lay

W Wu

C Robinette

M J Kesic

S C Dreskin

D B Peden

M Hernandez

Affiliations

Soon will be listed here.

Abstract

Epidemiologic studies suggest that dietary vitamin E is a candidate intervention for atopic disease. We used in vitro and ex vivo exposures to test the hypothesis that the most common dietary isoform of vitamin E, γ-tocopherol (γT), could suppress FcεRI-mediated basophil activation. Rat basophilic leukemia (RBL)-SX38 cells that express human FcεRI were treated with or without γT, followed by stimulation with α-IgE. In the ex vivo study, 20 Der f 1-allergic volunteers consumed a γT-enriched supplement for 7 days. Their basophils were challenged ex vivo with α-IgE and graded doses of Der f 1 before and after the supplementation period. γt treatment of RBL-SX38 cells significantly reduced basophil degranulation and de novo TH2 cytokine production. Daily consumption of a γT-rich supplement by dust mite-allergic volunteers reduced basophil activation after ex vivo dust mite challenge. Vitamin E supplements rich in γT may be useful adjuncts in decreasing atopic disease.

Citing Articles

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