Preoperative Hepatitis B Virus DNA Level is a Risk Factor for Postoperative Liver Failure in Patients Who Underwent Partial Hepatectomy for Hepatitis B-related Hepatocellular Carcinoma

Overview

Journal World J Surg

Publisher Wiley

Specialty General Surgery

Date 2014 Apr 4

PMID 24696061

Citations 7

Authors

Gang Huang

Wan Yee Lau

Feng Shen

Ze-Ya Pan

Si-Yuan Fu

Yun Yang

Wei-Ping Zhou

Meng-Chao Wu

Affiliations

Soon will be listed here.

Abstract

Objective: Our objective was to explore the short-term effects of preoperative serum hepatitis B virus DNA level (HBV DNA) on postoperative hepatic function in patients who underwent partial hepatectomy for hepatitis B-related hepatocellular carcinoma (HCC).

Methods: The clinical data of 1,602 patients with hepatitis B-related HCC who underwent partial hepatectomy in our department were retrospectively studied. The patients were divided into three groups according to their preoperative HBV DNA levels: group A <200 IU/mL, group B 200-20,000 IU/mL, and group C >20,000 IU/mL. The rates of postoperative complications, especially the rate of postoperative liver failure, were compared.

Results: There were significant differences among the three groups in the rates of postoperative liver failure. On multivariate logistic regression analysis, a high preoperative HBV DNA level was an independent risk factor for postoperative liver failure.

Conclusions: Preoperative HBV DNA level was a significant risk factor for postoperative hepatic dysfunction.

Citing Articles

Perioperative predictors of outcome of hepatectomy for HBV-related hepatocellular carcinoma.

He Z, Tang D Front Oncol. 2023; 13:1230164.

PMID: 37519791 PMC: 10373594. DOI: 10.3389/fonc.2023.1230164.

Clinical conditions and treatment requirements for long-term survival among hepatitis B-related hepatocellular carcinoma initially treated with chemoembolization.

Chen Z, Jian Z, Wu X, Wang J, Peng J, Lao X Cancer Med. 2019; 8(11):5097-5107.

PMID: 31313476 PMC: 6718579. DOI: 10.1002/cam4.2380.

Preoperative aspartate aminotransferase-to-platelet-ratio index as a predictor of posthepatectomy liver failure for resectable hepatocellular carcinoma.

Mai R, Ye J, Long Z, Shi X, Bai T, Chen J Cancer Manag Res. 2019; 11:1401-1414.

PMID: 30863151 PMC: 6388945. DOI: 10.2147/CMAR.S186114.

Impact of Preoperative Hepatitis B Virus Levels on Prognosis After Primary and Repeat Hepatectomies for Hepatocellular Carcinoma Patients-a Retrospective Study.

Yan P, Wang R, Zhang J, Cong W, Dong H, Yu H J Gastrointest Surg. 2018; 22(5):872-883.

PMID: 29313290 DOI: 10.1007/s11605-017-3638-0.

Prediction of posthepatectomy liver failure using transient elastography in patients with hepatitis B related hepatocellular carcinoma.

Lei J, Ji X, Hong J, Li W, Chen Y, Pan Y BMC Gastroenterol. 2017; 17(1):171.

PMID: 29284411 PMC: 5747264. DOI: 10.1186/s12876-017-0732-4.

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