Relationship Between Follicular Fluid Adipocytokines and the Quality of the Oocyte and Corresponding Embryo Development from a Single Dominant Follicle in in Vitro Fertilization/intracytoplasmic Sperm Injection Cycles

Overview

Journal Clin Exp Reprod Med

Date 2014 Apr 3

PMID 24693494

Citations 2

Authors

Hye Jin Chang

Ji Hyun Lee

Jung Ryeol Lee

Byung Chul Jee

Chang Suk Suh

Seok Hyun Kim

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the association of individual follicular fluid (FF) leptin and adiponectin levels with the quality of the corresponding oocyte and embryo.

Methods: We prospectively enrolled 67 women who underwent controlled ovarian hyperstimulation with 89 FF samples. FF and the corresponding oocyte was obtained from a single dominant preovulatory follicle at the time of oocyte retrieval. Concentrations of leptin and adiponectin were measured by enzyme-linked immunosorbent assay in an individual follicle. The oocyte quality, fertilization rate, and corresponding embryo development were assessed.

Results: The FF level of leptin was significantly associated with body mass index (r=0.334, p<0.01). The FF adiponectin level was significantly higher in the normal fertilization group than the abnormal fertilization group (p=0.009) in the non-obese women. A lower FF leptin level was associated with a trend toward mature oocytes, normal fertilization, and good embryo quality, although these relationships were not statistically significant. The leptin:adiponectin ratio of FF did not differ significantly according to oocyte and embryo quality. The quality of the oocyte and embryo was not associated with the FF leptin level tertile. However, the normal fertilization rate was positively associated with FF adiponectin level tertile. There was a trend towards improved oocytes and normal fertilization rates with the lowest tertile of the FF leptin:adiponectin ratio, but this difference was not statistically significant.

Conclusion: Our results suggest that a high FF adiponectin concentration could be a predictor of normal fertilization. However, the FF leptin concentration and leptin:adiponectin ratio is not significantly related to oocyte maturity and corresponding embryo development.

Citing Articles

Role of adiponectin in ovarian follicular development and ovarian reserve.

Merhi Z, Bazzi A, Bonney E, Buyuk E Biomed Rep. 2019; 1(1):1-5.

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Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis.

Goldsammler M, Merhi Z, Buyuk E Reprod Biol Endocrinol. 2018; 16(1):45.

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