Epidermal Barriers

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2014 Apr 3

PMID 24692192

Citations 31

Authors

Ken Natsuga

Affiliations

Soon will be listed here.

Abstract

The epidermis functions as a physical barrier to the external environment and works to prevent loss of water from the skin. Numerous factors have been implicated in the formation of epidermal barriers, such as cornified envelopes, corneocytes, lipids, junctional proteins, proteases, protease inhibitors, antimicrobial peptides, and transcription factors. This review illustrates human diseases (ichthyoses) and animal models in which the epidermal barrier is disrupted or dysfunctional at steady state owing to ablation of one or more of the above factors. These diseases and animal models help us to understand the complicated mechanisms of epidermal barrier formation and give further insights on epidermal development.

Citing Articles

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