Genetic Diversity and Prevalence of CCR2-CCR5 Gene Polymorphisms in the Omani Population

Overview

Journal Genet Mol Biol

Specialty Genetics

Date 2014 Apr 2

PMID 24688285

Citations 1

Authors

Samira H Al-Mahruqi

Fahad Zadjali

Albano Beja-Pereira

Crystal Y Koh

Abdullah Balkhair

Ali A Al-Jabri

Affiliations

Soon will be listed here.

Abstract

Polymorphisms in the regulatory region of the CCR5 gene affect protein expression and modulate the progress of HIV-1 disease. Because of this prominent role, variations in this gene have been under differential pressure and their frequencies vary among human populations. The CCR2V64I mutation is tightly linked to certain polymorphisms in the CCR5 gene. The current Omani population is genetically diverse, a reflection of their history as traders who ruled extensive regions around the Indian Ocean. In this study, we examined the CCR2-CCR5 haplotypes in Omanis and compared the patterns of genetic diversity with those of other populations. Blood samples were collected from 115 Omani adults and genomic DNA was screened to identify the polymorphic sites in the CCR5 gene and the CCR2V64I mutation. Four minor alleles were common: CCR5-2554T and CCR5-2086G showed frequencies of 49% and 46%, respectively, whereas CCR5-2459A and CCR5-2135C both had a frequency of 36%. These alleles showed moderate levels of heterozygosity, indicating that they were under balancing selection. However, the well-known allele CCR5Δ32 was relatively rare. Eleven haplotypes were identified, four of which were common: HHC (46%), HHE (20%), HHA (14%) and HHF*2 (12%).

Citing Articles

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PMID: 34179311 PMC: 8209322. DOI: 10.1016/j.gendis.2020.04.007.

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