Nanoengineered Particles for Enhanced Intra-articular Retention and Delivery of Proteins

Overview

Journal Adv Healthc Mater

Specialties Biomedical Engineering
Biotechnology

Date 2014 Apr 2

PMID 24687997

Citations 38

Authors

Ankur Singh

Rachit Agarwal

Carlos A Diaz-Ruiz

Nick J Willett

Peiyi Wang

L Andrew Lee

Qian Wang

Robert E Guldberg

Andres J Garcia

Affiliations

Soon will be listed here.

Abstract

Localized intra-articular delivery of anti-inflammatory proteins can reduce inflammation in osteoarthritis but poses a challenge because of raid clearance within few hours of injection. A new class of polymer is developed that forms self-assembled nanoparticles ranging from 300 to 900 nm and demonstrates particle size dependent prolonged retention in intra-articular joint spaces compared to bolus protein over a period of 14 d.

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