Dual Opposing Roles of Adaptive Immunity in Hypertension

Overview

Journal Eur Heart J

Publisher Oxford University Press

Specialty Cardiology & Vascular Diseases

Date 2014 Apr 2

PMID 24685711

Citations 42

Authors

Noureddine Idris-Khodja

Muhammad Oneeb Rehman Mian

Pierre Paradis

Ernesto L Schiffrin

Affiliations

Soon will be listed here.

Abstract

Hypertension involves remodelling and inflammation of the arterial wall. Interactions between vascular and inflammatory cells play a critical role in disease initiation and progression. T effector and regulatory lymphocytes, members of the adaptive immune system, play contrasting roles in hypertension. Signals from the central nervous system and the innate immune system antigen-presenting cells activate T effector lymphocytes and promote their differentiation towards pro-inflammatory T helper (Th) 1 and Th17 phenotypes. Th1 and Th17 effector cells, via production of pro-inflammatory mediators, participate in the low-grade inflammation that leads to blood pressure elevation and end-organ damage. T regulatory lymphocytes, on the other hand, counteract hypertensive effects by suppressing innate and adaptive immune responses. The present review summarizes and discusses the adaptive immune mechanisms that participate in the pathophysiology in hypertension.

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References

Armstrong A, Harskamp C, Armstrong E . The association between psoriasis and hypertension: a systematic review and meta-analysis of observational studies. J Hypertens. 2012; 31(3):433-42. DOI: 10.1097/HJH.0b013e32835bcce1. View

Sutton C, Lalor S, Sweeney C, Brereton C, Lavelle E, Mills K . Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity. 2009; 31(2):331-41. DOI: 10.1016/j.immuni.2009.08.001. View

Crowley S, Song Y, Sprung G, Griffiths R, Sparks M, Yan M . A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. Hypertension. 2009; 55(1):99-108. PMC: 3676183. DOI: 10.1161/HYPERTENSIONAHA.109.144964. View

Didion S, Kinzenbaw D, Schrader L, Chu Y, Faraci F . Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction. Hypertension. 2009; 54(3):619-24. PMC: 2861503. DOI: 10.1161/HYPERTENSIONAHA.109.137158. View

Smart Y, Gillies A, Waga S, Carney S, Smith A, Burton R . Effects of captopril on circulating T lymphocyte subsets. Int J Clin Pharmacol Ther Toxicol. 1987; 25(7):389-91. View

Wang Y, Alexander S . CD8 regulatory T cells: what's old is now new. Immunol Cell Biol. 2009; 87(3):192-3. DOI: 10.1038/icb.2009.8. View

J Blake G, Rifai N, Buring J, Ridker P . Blood pressure, C-reactive protein, and risk of future cardiovascular events. Circulation. 2003; 108(24):2993-9. DOI: 10.1161/01.CIR.0000104566.10178.AF. View

Guzik T, Hoch N, Brown K, McCann L, Rahman A, Dikalov S . Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007; 204(10):2449-60. PMC: 2118469. DOI: 10.1084/jem.20070657. View

Hang L, Henry J, Dixon F . Transfer of renovascular hypertension and coronary heart disease by lymphoid cells from SLE-prone mice. Am J Pathol. 1984; 115(1):42-6. PMC: 1900344. View

10.

Matrougui K, Abd ElMageed Z, Zakaria A, Kassan M, Choi S, Nair D . Natural regulatory T cells control coronary arteriolar endothelial dysfunction in hypertensive mice. Am J Pathol. 2011; 178(1):434-41. PMC: 3069876. DOI: 10.1016/j.ajpath.2010.11.034. View

11.

Gratze P, Dechend R, Stocker C, Park J, Feldt S, Shagdarsuren E . Novel role for inhibitor of differentiation 2 in the genesis of angiotensin II-induced hypertension. Circulation. 2008; 117(20):2645-56. DOI: 10.1161/CIRCULATIONAHA.107.760116. View

12.

Madhur M, Lob H, McCann L, Iwakura Y, Blinder Y, Guzik T . Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction. Hypertension. 2009; 55(2):500-7. PMC: 2819301. DOI: 10.1161/HYPERTENSIONAHA.109.145094. View

13.

Rodriguez-Iturbe B, Quiroz Y, Nava M, Bonet L, Chavez M, Herrera-Acosta J . Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats. Am J Physiol Renal Physiol. 2002; 282(2):F191-201. DOI: 10.1152/ajprenal.0197.2001. View

14.

Vignali D, Collison L, Workman C . How regulatory T cells work. Nat Rev Immunol. 2008; 8(7):523-32. PMC: 2665249. DOI: 10.1038/nri2343. View

15.

Olsen F, Rasmussen S . Delayed hypersensitivity and borderline essential hypertension. Acta Pathol Microbiol Scand C. 1977; 85(3):196-8. View

16.

Kasal D, Barhoumi T, Li M, Yamamoto N, Zdanovich E, Rehman A . T regulatory lymphocytes prevent aldosterone-induced vascular injury. Hypertension. 2011; 59(2):324-30. DOI: 10.1161/HYPERTENSIONAHA.111.181123. View

17.

Rodriguez-Iturbe B, Quiroz Y, Ferrebuz A, Parra G, Vaziri N . Evolution of renal interstitial inflammation and NF-kappaB activation in spontaneously hypertensive rats. Am J Nephrol. 2004; 24(6):587-94. DOI: 10.1159/000082313. View

18.

Norman Jr R, Dzielak D, Bost K, Khraibi A, Galloway P . Immune system dysfunction contributes to the aetiology of spontaneous hypertension. J Hypertens. 1985; 3(3):261-8. DOI: 10.1097/00004872-198506000-00011. View

19.

Amador C, Barrientos V, Pena J, Herrada A, Gonzalez M, Valdes S . Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes. Hypertension. 2014; 63(4):797-803. DOI: 10.1161/HYPERTENSIONAHA.113.02883. View

20.

Dzielak D . Interleukin-2 and spontaneous hypertension. Hypertension. 1991; 18(2):171-5. DOI: 10.1161/01.hyp.18.2.171. View