Effects of Endurance Exercise on Expressions of Glial Fibrillary Acidic Protein and Myelin Basic Protein in Developing Rats with Maternal Infection-induced Cerebral Palsy

Overview

Journal J Exerc Rehabil

Date 2014 Mar 29

PMID 24678499

Citations 7

Authors

Kijeong Kim

Mal-Soon Shin

Han-Sam Cho

Young-Pyo Kim

Affiliations

Soon will be listed here.

Abstract

Periventricular leukomalacia (PVL) is a common white matter lesion affecting the neonatal brain. PVL is closely associated with cerebral palsy (CP) and characterized by increase in the number of astrocytes, which can be detected by positivity for glial fibrillary acidic protein (GFAP). Change in myelin basic protein (MBP) is an early sign of white matter abnormality. Maternal or placental infection can damage the neonatal brain. In the present study, we investigated the effects of treadmill walking exercise on GFAP and MBP expressions in rats with maternal lipopolysaccharide (LPS)-induced PVL. Immunohistochemistry was performed for the detection of GFAP and MBP. The present results showed that intracervical maternal LPS injection during pregnancy increased GFAP expression in the striatum and decreased MBP expression in the corpus callosum of rats. The results also showed that treadmill walking exercise suppressed GFAP expression and enhanced MBP expression in the brains of rats with maternal LPS-induced PVL. The present study revealed that treadmill walking exercise is effective for the suppressing astrogliosis and hypomyelination associated with PVL. Here in this study, we showed that treadmill walking exercise may be effective therapeutic strategy for alleviating the detrimental effects of CP.

Citing Articles

[Intrauterine infection affects early growth and neurobehavioral development in neonatal rats].

Shen Y, Sun Y, Gu W, Yu H, Yuan T Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019; 48(1):58-64.

PMID: 31102359 PMC: 8800657. DOI: 10.3785/j.issn.1008-9292.2019.02.10.

Spatially Resolved Proteome Mapping of Laser Capture Microdissected Tissue with Automated Sample Transfer to Nanodroplets.

Zhu Y, Dou M, Piehowski P, Liang Y, Wang F, Chu R Mol Cell Proteomics. 2018; 17(9):1864-1874.

PMID: 29941660 PMC: 6126383. DOI: 10.1074/mcp.TIR118.000686.

Beneficial effects of Jiawei Shenqi-wan and treadmill training on deficits associated with neonatal hypoxic-ischemia in rats.

Kim H, Pak M, Shin M, Kim S, Shin Y, Yun Y Exp Ther Med. 2017; 13(5):2134-2142.

PMID: 28565820 PMC: 5443215. DOI: 10.3892/etm.2017.4286.

Treadmill exercise ameliorates symptoms of Alzheimer disease through suppressing microglial activation-induced apoptosis in rats.

Baek S, Kim S J Exerc Rehabil. 2017; 12(6):526-534.

PMID: 28119873 PMC: 5227313. DOI: 10.12965/jer.1632858.429.

Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats.

Kim K, Sung Y, Seo J, Lee S, Lim B, Lee C J Exerc Rehabil. 2016; 11(6):296-302.

PMID: 26730379 PMC: 4697777. DOI: 10.12965/jer.150264.

References

Wozniak D, Hartman R, Boyle M, Vogt S, Brooks A, Tenkova T . Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis. 2004; 17(3):403-14. DOI: 10.1016/j.nbd.2004.08.006. View

Kurumatani T, Kudo T, Ikura Y, Takeda M . White matter changes in the gerbil brain under chronic cerebral hypoperfusion. Stroke. 1998; 29(5):1058-62. DOI: 10.1161/01.str.29.5.1058. View

Tong L, Shen H, Perreau V, Balazs R, Cotman C . Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis. 2001; 8(6):1046-56. DOI: 10.1006/nbdi.2001.0427. View

Kim S, Ko I, Park C, Shin M, Kim C, Jee Y . Treadmill and wheel exercise alleviate lipopolysaccharide-induced short-term memory impairment by enhancing neuronal maturation in rats. Mol Med Rep. 2012; 7(1):31-6. DOI: 10.3892/mmr.2012.1160. View

Leviton A, Dammann O . Coagulation, inflammation, and the risk of neonatal white matter damage. Pediatr Res. 2004; 55(4):541-5. DOI: 10.1203/01.PDR.0000121197.24154.82. View

Bucinskaite V, Theodorsson E, Crumpton K, Stenfors C, Ekblom A, Lundeberg T . Effects of repeated sensory stimulation (electro-acupuncture) and physical exercise (running) on open-field behaviour and concentrations of neuropeptides in the hippocampus in WKY and SHR rats. Eur J Neurosci. 1996; 8(2):382-7. DOI: 10.1111/j.1460-9568.1996.tb01221.x. View

Balasingam V, Wright E, Bouckova R, Yong V . Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci. 1994; 14(2):846-56. PMC: 6576825. View

Adams-Chapman I, Stoll B . Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Curr Opin Infect Dis. 2006; 19(3):290-7. DOI: 10.1097/01.qco.0000224825.57976.87. View

Deguchi K, Oguchi K, Takashima S . Characteristic neuropathology of leukomalacia in extremely low birth weight infants. Pediatr Neurol. 1997; 16(4):296-300. DOI: 10.1016/s0887-8994(97)00041-6. View

10.

Wang X, Rousset C, Hagberg H, Mallard C . Lipopolysaccharide-induced inflammation and perinatal brain injury. Semin Fetal Neonatal Med. 2006; 11(5):343-53. DOI: 10.1016/j.siny.2006.04.002. View

11.

Sutoo D, Akiyama K . The mechanism by which exercise modifies brain function. Physiol Behav. 1996; 60(1):177-81. DOI: 10.1016/0031-9384(96)00011-x. View

12.

OBONAI T, Asanuma M, Mizuta R, Horie H, Tanaka J, Takashima S . Evidence of brain ischemia in early neonatal sudden death syndrome. Neuropediatrics. 1997; 28(3):145-8. DOI: 10.1055/s-2007-973691. View

13.

Ra S, Kim H, Jang M, Shin M, Lee T, Lim B . Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats. Neurosci Lett. 2002; 333(2):123-6. DOI: 10.1016/s0304-3940(02)01031-5. View

14.

Goepfert A, Andrews W, Carlo W, Ramsey P, Cliver S, Goldenberg R . Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity. Am J Obstet Gynecol. 2004; 191(4):1375-81. DOI: 10.1016/j.ajog.2004.06.086. View

15.

Zlokovic B, Zhang C, Liu D, Fernandez J, Griffin J, Chopp M . Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005; 58(3):474-7. DOI: 10.1002/ana.20602. View

16.

Toso L, Poggi S, Park J, Einat H, Roberson R, Dunlap V . Inflammatory-mediated model of cerebral palsy with developmental sequelae. Am J Obstet Gynecol. 2005; 193(3 Pt 2):933-41. DOI: 10.1016/j.ajog.2005.05.072. View

17.

Bell M, Hallenbeck J . Effects of intrauterine inflammation on developing rat brain. J Neurosci Res. 2002; 70(4):570-9. DOI: 10.1002/jnr.10423. View

18.

Russo-Neustadt A, Beard R, Cotman C . Exercise, antidepressant medications, and enhanced brain derived neurotrophic factor expression. Neuropsychopharmacology. 1999; 21(5):679-82. DOI: 10.1016/S0893-133X(99)00059-7. View

19.

Hagberg H, Peebles D, Mallard C . Models of white matter injury: comparison of infectious, hypoxic-ischemic, and excitotoxic insults. Ment Retard Dev Disabil Res Rev. 2002; 8(1):30-8. DOI: 10.1002/mrdd.10007. View

20.

Adams-Chapman I . Neurodevelopmental outcome of the late preterm infant. Clin Perinatol. 2006; 33(4):947-64. DOI: 10.1016/j.clp.2006.09.004. View