An Overview of Amines As Nutritional Supplements to Counteract Cancer Cachexia

Overview

Journal J Cachexia Sarcopenia Muscle

Date 2014 Mar 29

PMID 24676930

Citations 16

Authors

Patricia Lopes de Campos-Ferraz

Isabel Andrade

Willian das Neves

Isabela Hangai

Christiano Robles Rodrigues Alves

Antonio Herbert Lancha Jr

Affiliations

Soon will be listed here.

Abstract

Cancer cachexia is a complex multifactorial syndrome characterized by loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment. Recently, some amino acids and other amine dietary supplements have been highlighted in medical field due to positive effects upon diseases evolving skeletal muscle atrophy. Therefore, the aim of this brief review is to discuss the putative application of amines as dietary supplements to counteract skeletal muscle wasting on cancer cachexia. Specifically, we focus in two nutritional supplements: (1) branched-chain amino acids (BCAAs) and (2) creatine. Both BCAAs and creatine may attenuate proteolysis and enhance proteins synthesis in skeletal muscle. Although more experimental studies and clinical trials are still necessary to elucidate this therapeutic application, several evidences have demonstrated that amines supplementation is a promising coadjuvant treatment to cancer cachexia.

Citing Articles

Acetate Alleviates Gut Microbiota Depletion-Induced Retardation of Skeletal Muscle Growth and Development in Young Mice.

Yang G, Zhang J, Liu Y, Sun J, Ge L, Lu L Int J Mol Sci. 2024; 25(10).

PMID: 38791168 PMC: 11121558. DOI: 10.3390/ijms25105129.

Research progress on branched-chain amino acid aminotransferases.

Chen C, Naveed H, Chen K Front Genet. 2023; 14:1233669.

PMID: 38028625 PMC: 10658711. DOI: 10.3389/fgene.2023.1233669.

A Review of Nutraceuticals in Cancer Cachexia.

Caeiro L, Gandhay D, Anderson L, Garcia J Cancers (Basel). 2023; 15(15).

PMID: 37568700 PMC: 10417577. DOI: 10.3390/cancers15153884.

The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology.

Dimou A, Tsimihodimos V, Bairaktari E Int J Mol Sci. 2022; 23(7).

PMID: 35409380 PMC: 8999875. DOI: 10.3390/ijms23074022.

Branched-Chain Amino Acids Can Predict Mortality in ICU Sepsis Patients.

Reisinger A, Posch F, Hackl G, Marsche G, Sourij H, Bourgeois B Nutrients. 2021; 13(9).

PMID: 34578983 PMC: 8469152. DOI: 10.3390/nu13093106.

References

Fearon K, Strasser F, Anker S, Bosaeus I, Bruera E, Fainsinger R . Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011; 12(5):489-95. DOI: 10.1016/S1470-2045(10)70218-7. View

Nicastro H, da Luz C, Seixas Chaves D, Grassmann Bechara L, Voltarelli V, Rogero M . Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. J Nutr Metab. 2012; 2012:136937. PMC: 3321450. DOI: 10.1155/2012/136937. View

Gomes-Marcondes M, Ventrucci G, Toledo M, Cury L, Cooper J . A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats. Braz J Med Biol Res. 2003; 36(11):1589-94. DOI: 10.1590/s0100-879x2003001100017. View

Yamanaka H, Kanemaki T, Tsuji M, Kise Y, Hatano T, Hioki K . Branched-chain amino acid-supplemented nutritional support after gastrectomy for gastric cancer with special reference to plasma amino acid profiles. Nutrition. 1990; 6(3):241-5. View

Nicastro H, Artioli G, Dos Santos Costa A, Solis M, da Luz C, Blachier F . An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions. Amino Acids. 2010; 40(2):287-300. DOI: 10.1007/s00726-010-0636-x. View

Tarnopolsky M . Caffeine and creatine use in sport. Ann Nutr Metab. 2011; 57 Suppl 2:1-8. DOI: 10.1159/000322696. View

Shimomura Y, Yamamoto Y, Bajotto G, Sato J, Murakami T, Shimomura N . Nutraceutical effects of branched-chain amino acids on skeletal muscle. J Nutr. 2006; 136(2):529S-532S. DOI: 10.1093/jn/136.2.529S. View

Cangiano C, Laviano A, Meguid M, Mulieri M, Conversano L, Preziosa I . Effects of administration of oral branched-chain amino acids on anorexia and caloric intake in cancer patients. J Natl Cancer Inst. 1996; 88(8):550-2. DOI: 10.1093/jnci/88.8.550. View

Norman K, Stubler D, Baier P, Schutz T, Ocran K, Holm E . Effects of creatine supplementation on nutritional status, muscle function and quality of life in patients with colorectal cancer--a double blind randomised controlled trial. Clin Nutr. 2006; 25(4):596-605. DOI: 10.1016/j.clnu.2006.01.014. View

10.

Smith H, Wyke S, Tisdale M . Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate. Cancer Res. 2004; 64(23):8731-5. DOI: 10.1158/0008-5472.CAN-04-1760. View

11.

Argiles J, Lopez-Soriano F, Busquets S . Mechanisms and treatment of cancer cachexia. Nutr Metab Cardiovasc Dis. 2012; 23 Suppl 1:S19-24. DOI: 10.1016/j.numecd.2012.04.011. View

12.

Rawson E, Venezia A . Use of creatine in the elderly and evidence for effects on cognitive function in young and old. Amino Acids. 2011; 40(5):1349-62. DOI: 10.1007/s00726-011-0855-9. View

13.

Harris R, Soderlund K, Hultman E . Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992; 83(3):367-74. DOI: 10.1042/cs0830367. View

14.

Nunes E, Kuczera D, Brito G, Bonatto S, Yamazaki R, Tanhoffer R . Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression. Nutr Res. 2008; 28(7):487-93. DOI: 10.1016/j.nutres.2008.04.006. View

15.

Wilson G, Wilson J, Manninen A . Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review. Nutr Metab (Lond). 2008; 5:1. PMC: 2245953. DOI: 10.1186/1743-7075-5-1. View

16.

Patra S, Bera S, SinhaRoy S, Ghoshal S, Ray S, Basu A . Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma. FEBS J. 2008; 275(12):3236-47. DOI: 10.1111/j.1742-4658.2008.06475.x. View

17.

Molfino A, Gioia G, Fanelli F, Muscaritoli M . Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials. Amino Acids. 2013; 45(6):1273-92. DOI: 10.1007/s00726-013-1592-z. View

18.

Tarnopolsky M . Creatine as a therapeutic strategy for myopathies. Amino Acids. 2011; 40(5):1397-407. DOI: 10.1007/s00726-011-0876-4. View

19.

Aversa Z, Bonetto A, Costelli P, Minero V, Penna F, Baccino F . β-hydroxy-β-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. Int J Oncol. 2010; 38(3):713-20. DOI: 10.3892/ijo.2010.885. View

20.

Fearon K, Glass D, Guttridge D . Cancer cachexia: mediators, signaling, and metabolic pathways. Cell Metab. 2012; 16(2):153-66. DOI: 10.1016/j.cmet.2012.06.011. View