Immune Response and the Tumor Microenvironment: How They Communicate to Regulate Gastric Cancer

Overview

Journal Gut Liver

Specialty Gastroenterology

Date 2014 Mar 28

PMID 24672653

Citations 92

Authors

Keunwook Lee

Hyekyung Hwang

Ki Taek Nam

Affiliations

Soon will be listed here.

Abstract

Gastric cancer is the second most common cause of cancer-related death in the world. A growing body of evidence indicates that inflammation is closely associated with the initiation, progression, and metastasis of many tumors, including those of gastric cancer. In addition, approximately 60% of the world's population is colonized by Helicobacter pylori, which accounts for more than 50% of gastric cancers. While the role of inflammation in intestinal and colonic cancers is relatively well defined, its role in stomach neoplasia is still unclear because of the limited access of pathogens to the acidic environment and the technical difficulties isolating and characterizing immune cells in the stomach, especially in animal models. In this review, we will provide recent updates addressing how inflammation is involved in gastric malignancies, and what immune characteristics regulate the pathogenesis of stomach cancer. Also, we will discuss potential therapeutics that target the immune system for the efficient treatment of gastric cancer.

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References

El-Omar E, Carrington M, Chow W, McColl K, Bream J, Young H . The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer. Nature. 2002; 412(6842):99. DOI: 10.1038/35083631. View

Nomi T, Sho M, Akahori T, Hamada K, Kubo A, Kanehiro H . Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer. Clin Cancer Res. 2007; 13(7):2151-7. DOI: 10.1158/1078-0432.CCR-06-2746. View

Gao Q, Qiu S, Fan J, Zhou J, Wang X, Xiao Y . Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol. 2007; 25(18):2586-93. DOI: 10.1200/JCO.2006.09.4565. View

Monteleone G, Del Vecchio Blanco G, Palmieri G, Vavassori P, Monteleone I, Colantoni A . Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection. Gastroenterology. 2004; 126(3):674-82. DOI: 10.1053/j.gastro.2003.11.048. View

Sangiolo D . Cytokine induced killer cells as promising immunotherapy for solid tumors. J Cancer. 2011; 2:363-8. PMC: 3119405. DOI: 10.7150/jca.2.363. View

Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T . Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med. 2000; 192(11):1601-10. PMC: 2193104. DOI: 10.1084/jem.192.11.1601. View

Prinz C, Schoniger M, Rad R, Becker I, KEIDITSCH E, Wagenpfeil S . Key importance of the Helicobacter pylori adherence factor blood group antigen binding adhesin during chronic gastric inflammation. Cancer Res. 2001; 61(5):1903-9. View

Biswas S, Mantovani A . Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010; 11(10):889-96. DOI: 10.1038/ni.1937. View

Yokota S, Okabayashi T, Rehli M, Fujii N, Amano K . Helicobacter pylori lipopolysaccharides upregulate toll-like receptor 4 expression and proliferation of gastric epithelial cells via the MEK1/2-ERK1/2 mitogen-activated protein kinase pathway. Infect Immun. 2009; 78(1):468-76. PMC: 2798195. DOI: 10.1128/IAI.00903-09. View

10.

Parsonnet J, Friedman G, ORENTREICH N, Vogelman H . Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut. 1997; 40(3):297-301. PMC: 1027076. DOI: 10.1136/gut.40.3.297. View

11.

Canedo P, Corso G, Pereira F, Lunet N, Suriano G, Figueiredo C . The interferon gamma receptor 1 (IFNGR1) -56C/T gene polymorphism is associated with increased risk of early gastric carcinoma. Gut. 2008; 57(11):1504-8. DOI: 10.1136/gut.2007.143578. View

12.

Kennedy C, Najdovska M, Jones G, McLeod L, Hughes N, Allison C . The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. J Pathol. 2011; 225(2):255-64. DOI: 10.1002/path.2933. View

13.

Koebel C, Vermi W, Swann J, Zerafa N, Rodig S, Old L . Adaptive immunity maintains occult cancer in an equilibrium state. Nature. 2007; 450(7171):903-7. DOI: 10.1038/nature06309. View

14.

Taketo M . Role of bone marrow-derived cells in colon cancer: lessons from mouse model studies. J Gastroenterol. 2009; 44(2):93-102. DOI: 10.1007/s00535-008-2321-3. View

15.

Stairs D, Bayne L, Rhoades B, Vega M, Waldron T, Kalabis J . Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene. Cancer Cell. 2011; 19(4):470-83. PMC: 3077713. DOI: 10.1016/j.ccr.2011.02.007. View

16.

Gooden M, de Bock G, Leffers N, Daemen T, Nijman H . The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer. 2011; 105(1):93-103. PMC: 3137407. DOI: 10.1038/bjc.2011.189. View

17.

Fehlings M, Drobbe L, Moos V, Viveros P, Hagen J, Beigier-Bompadre M . Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells, macrophages, and monocytes. Infect Immun. 2012; 80(8):2724-34. PMC: 3434561. DOI: 10.1128/IAI.00381-12. View

18.

Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pages C . Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006; 313(5795):1960-4. DOI: 10.1126/science.1129139. View

19.

Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T . Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 2010; 70(4):1430-40. DOI: 10.1158/0008-5472.CAN-09-2755. View

20.

Zhou Y, Toh M, Zrioual S, Miossec P . IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells. Cytokine. 2007; 38(3):157-64. DOI: 10.1016/j.cyto.2007.06.002. View