Examination of the Ovarian Reserve After Generation of Unilateral Rudimentary Uterine Horns in Rats

Overview

Journal ScientificWorldJournal

Publisher Wiley

Specialty Biology

Date 2014 Mar 28

PMID 24672393

Citations 2

Authors

Hasan Toyganozu

Hakan Nazik

Raziye Narin

Deniz Satar

Mehmet Ali Narin

Sinem Buyuknacar

Murat Api

Hakan Aytan

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this experimental rat model study is to evaluate the changes in the ovarian environment after excision of the rudimentary horn.

Methods: Ten female Wistar albino rats were used in this study. One cm of right uterine horn length was excised in the first operation. Two months after the first operation, all animals were sacrificed to obtain ovaries for histological examination. Mann-Whitney U test and Student's t-test were used for statistical analysis purposes. Statistical significance was defined as P < 0.005.

Results: The number of primordial follicles (P = 0.415), primary follicles (P = 0.959), preantral follicles (P = 0.645), antral follicles (P = 0.328), and Graafian follicles (P = 0.721) was decreased and the number of atretic follicles (P = 0.374) increased in the right ovarian side. Howeve,r this difference was not found to be statistically significant.

Conclusion: The results of this experimental rat model study suggest that the excision of rudimentary horn could have negative effects on ipsilateral ovarian functions.

Citing Articles

Evaluation of the relationship between ovarian reserve with congenital anomalies and intramural uterine leiomyoma among infertile women: a cross-sectional study.

Moini A, Kalhor M, Jahanian Sadatmahalleh S, Niknejadi M, Nasiri M, Yahyaei A J Ovarian Res. 2023; 16(1):68.

PMID: 37024902 PMC: 10080793. DOI: 10.1186/s13048-023-01149-7.

Comparative study on induction and effects of surgical menopause in a female rat model: a prospective case control study.

Moiety F, Salem H, Mehanna R, Abdel-Ghany B Int J Clin Exp Med. 2015; 8(6):9403-11.

PMID: 26309602 PMC: 4538166.

References

Gentile G, Kaufman S, Helbig D . Is there any evidence for a post-tubal sterilization syndrome?. Fertil Steril. 1998; 69(2):179-86. DOI: 10.1016/s0015-0282(97)00229-x. View

Fanchin R, Schonauer L, Righini C, Guibourdenche J, Frydman R, Taieb J . Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3. Hum Reprod. 2003; 18(2):323-7. DOI: 10.1093/humrep/deg042. View

Nahum G . Uterine anomalies. How common are they, and what is their distribution among subtypes?. J Reprod Med. 1998; 43(10):877-87. View

Chalmers C, Lindsay M, Usher D, Warner P, Evans D, Ferguson M . Hysterectomy and ovarian function: levels of follicle stimulating hormone and incidence of menopausal symptoms are not affected by hysterectomy in women under age 45 years. Climacteric. 2003; 5(4):366-73. View

Radwanska E, Headley S, Dmowski P . Evaluation of ovarian function after tubal sterilization. J Reprod Med. 1982; 27(7):376-84. View

Oldenhave A, Jaszmann L, Everaerd W, HASPELS A . Hysterectomized women with ovarian conservation report more severe climacteric complaints than do normal climacteric women of similar age. Am J Obstet Gynecol. 1993; 168(3 Pt 1):765-71. DOI: 10.1016/s0002-9378(12)90816-9. View

Chalmers C . Does hysterectomy in a premenopausal woman affect ovarian function?. Med Hypotheses. 1996; 46(6):573-5. DOI: 10.1016/s0306-9877(96)90134-6. View

Tiras M, Noyan V, Ozdemir H, Guner H, Yildiz A, Yildirim M . The changes in ovarian hormone levels and ovarian artery blood flow rate after laparoscopic tubal sterilization. Eur J Obstet Gynecol Reprod Biol. 2002; 99(2):219-21. DOI: 10.1016/s0301-2115(01)00410-9. View

Tapisiz O, Gungor T, Aytan H, Zergeroglu S, Mulazimoglu B, Bilge U . Does hysterectomy affect ovarian function? Histopathologic evaluation and serum FSH, inhibin A, and inhibin B levels in an experimental rat model. Eur J Obstet Gynecol Reprod Biol. 2008; 140(1):61-6. DOI: 10.1016/j.ejogrb.2008.04.001. View

10.

Hakverdi A, Taner C, Erden A, Satici O . Changes in ovarian function after tubal sterilization. Adv Contracept. 1994; 10(1):51-6. DOI: 10.1007/BF01986530. View

11.

Reichman D, Laufer M, Robinson B . Pregnancy outcomes in unicornuate uteri: a review. Fertil Steril. 2008; 91(5):1886-94. DOI: 10.1016/j.fertnstert.2008.02.163. View

12.

Heinonen P . Unicornuate uterus and rudimentary horn. Fertil Steril. 1997; 68(2):224-30. DOI: 10.1016/s0015-0282(97)81506-3. View

13.

Wu E, Xiao B, Yan W, Li H, Wu B . Hormonal profile of the menstrual cycle in Chinese women after tubal sterilization. Contraception. 1992; 45(6):583-93. DOI: 10.1016/0010-7824(92)90109-7. View

14.

Cevrioglu A, Degirmenci B, Acar M, Yilmazer M, Erol D, Kahraman A . Examination of changes caused by tubal sterilization in ovarian hormone secretion and uterine and ovarian artery blood flow rates. Contraception. 2004; 70(6):467-73. DOI: 10.1016/j.contraception.2004.08.004. View

15.

Vuorento T, Maenpaa J, Huhtaniemi I . Follow-up of ovarian endocrine function in premenopausal women after hysterectomy by daily measurements of salivary progesterone. Clin Endocrinol (Oxf). 1992; 36(5):505-10. DOI: 10.1111/j.1365-2265.1992.tb02253.x. View

16.

Derksen J, Brolmann H, Wiegerinck M, Vader H, Heintz A . The effect of hysterectomy and endometrial ablation on follicle stimulating hormone (FSH) levels up to 1 year after surgery. Maturitas. 1998; 29(2):133-8. DOI: 10.1016/s0378-5122(98)00018-8. View

17.

La Marca A, Stabile G, Artenisio A, Volpe A . Serum anti-Mullerian hormone throughout the human menstrual cycle. Hum Reprod. 2006; 21(12):3103-7. DOI: 10.1093/humrep/del291. View

18.

Zanetti E, Ferrari L, Rossi G . Classification and radiographic features of uterine malformations: hysterosalpingographic study. Br J Radiol. 1978; 51(603):161-70. DOI: 10.1259/0007-1285-51-603-161. View

19.

Simpson J, MacInnis R, English D, Gertig D, Morris H, Giles G . A comparison of estradiol levels between women with a hysterectomy and ovarian conservation and women with an intact uterus. Climacteric. 2006; 8(3):300-3. DOI: 10.1080/13697130500186560. View

20.

Thranov I, Hertz J, Kjer J, Andresen A, Micic S, Nielsen J . Hormonal and menstrual changes after laparoscopic sterilization by Falope-rings or Filshie-clips. Fertil Steril. 1992; 57(4):751-5. View