Prevalence of Human Herpesviridae in Cerebrospinal Fluid of Patients with Multiple Sclerosis and Noninfectious Neurological Disease in the Netherlands

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2014 Mar 28

PMID 24671719

Citations 5

Authors

Gijsbert P van Nierop

Rogier Q Hintzen

Georges M G M Verjans

Affiliations

Soon will be listed here.

Abstract

Prevalence of eight human herpesviruses (HHV1-8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1-8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behçets' disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1-8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.

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