Thymic Stromal Lymphopoietin is Expressed in the Intact Central Nervous System and Upregulated in the Myelin-degenerative Central Nervous System

Overview

Journal Glia

Specialty Neurology

Date 2014 Mar 27

PMID 24668732

Citations 8

Authors

Maja Kitic

Isabella Wimmer

Milena Adzemovic

Nikolaus Kogl

Antonia Rudel

Hans Lassmann

Monika Bradl

Affiliations

Soon will be listed here.

Abstract

Thymic stromal lymphopoietin (TSLP) is an epithelial cytokine expressed at barrier surfaces of the skin, gut, nose, lung, and the maternal/fetal interphase. At these sites, it is important for the generation and maintenance of non-inflammatory, tissue-resident dendritic cell responses. We show here that TSLP is also expressed in the central nervous system (CNS) where it is produced by choroid plexus epithelial cells and astrocytes in the spinal cord. Under conditions of low-grade myelin degeneration, the numbers of TSLP-expressing astrocytes increase, and microglia express transcripts for the functional TSLP receptor dimer indicating that these cells are targets for TSLP in the myelin-degenerative CNS.

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