Percutaneous Bone Marrow Transplantation Using Fractional Ablative Erbium:YAG Laser

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2014 Mar 27

PMID 24667438

Citations 1

Authors

Luis Rodriguez-Menocal

Marcela Salgado

Stephen Davis

Jill Waibel

Arsalan Shabbir

Audrey Cox

Evangelos V Badiavas

Affiliations

Soon will be listed here.

Abstract

Topical application of therapeutic agents has been a mainstay in Dermatology for the treatment of skin disorders but is not commonly used for systemic delivery. For a topically applied agent to reach distant body sites it must first overcome the barrier function of the skin and then penetrate into deeper structures before reaching the systemic circulation. This has limited the use of topically applied agents to those having specific charge, solubility and size restrictions. Pretreatment of the skin with ablative fractional laser appears to enhance the uptake of some topically applied drugs but the ability to effectively deliver agents to distant sites is largely unproven. In this report we used a fractional ablative Erb:YAG (Erbium/Yttrium Aluminum Garnet) laser to facilitate the transfer of bone marrow stem cells through the skin in a murine bone marrow transplant model. Chimerism could be detected in the peripheral blood of recipient C57BL/6 mice that were pretreated with ablative fractional laser and had topically applied enhanced green fluorescent protein (GFP) labeled bone marrow cells from syngeneic donor transgenic mice. This study indicates that fractional laser can be used to deliver stem cells through the skin and remain functionally intact.

Citing Articles

Fetal Fibroblast Transplantation via Ablative Fractional Laser Irradiation Reduces Scarring.

Sakai S, Aramaki-Hattori N, Kishi K Biomedicines. 2023; 11(2).

PMID: 36830884 PMC: 9953175. DOI: 10.3390/biomedicines11020347.

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