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SWATH™- and ITRAQ-based Quantitative Proteomic Analyses Reveal an Overexpression and Biological Relevance of CD109 in Advanced NSCLC

Overview
Journal J Proteomics
Publisher Elsevier
Specialty Biochemistry
Date 2014 Mar 27
PMID 24667143
Citations 17
Authors
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Abstract

Biological Significance: We simultaneously applied two quantitative proteomic approaches-iTRAQ-labeling and SWATH™-to analyze the secretome of metastatic cell lines, in order to explore the cancer-associated proteins in conditioned media. In this study, our results indicate that CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC.

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