Pragmatic Language in Autism and Fragile X Syndrome: Genetic and Clinical Applications

Overview

Journal Perspect Lang Learn Educ

Date 2014 Mar 25

PMID 24660047

Citations 13

Authors

Molly Losh

Gary E Martin

Jessica Klusek

Abigail L Hogan-Brown

Affiliations

Soon will be listed here.

Abstract

Evidence suggests a strong genetic basis to autism. Our research program focuses on identifying genetically meaningful phenotypes in autism, through family-genetic and cross-population methods, with a particular focus on language and social phenotypes that have been shown to aggregate in families of individuals with autism. In this article, we discuss recent findings from family study research implicating particular language and personality features as markers for genetic liability to autism and fragile X syndrome and -related variation in relatives. We conclude with consideration of the clinical implications of such findings.

Citing Articles

A longitudinal investigation of pragmatic language across contexts in autism and related neurodevelopmental conditions.

Martin G, Lee M, Bicknell K, Goodkind A, Maltman N, Losh M Front Neurol. 2023; 14:1155691.

PMID: 37545730 PMC: 10402743. DOI: 10.3389/fneur.2023.1155691.

Comparison of Linguistic Error Production in Conversational Language Among Boys With Fragile X Syndrome + Autism Spectrum Disorder and Autistic Boys.

Maltman N, Hilvert E, Friedman L, Sterling A J Speech Lang Hear Res. 2023; 66(1):296-313.

PMID: 36599155 PMC: 10023176. DOI: 10.1044/2022_JSLHR-22-00078.

Neural Processing of Speech Sounds in ASD and First-Degree Relatives.

Patel S, Winston M, Guilfoyle J, Nicol T, Martin G, Nayar K J Autism Dev Disord. 2022; 53(8):3257-3271.

PMID: 35672616 PMC: 10019095. DOI: 10.1007/s10803-022-05562-7.

Childhood Academic Performance: A Potential Marker of Genetic Liability to Autism.

Guilfoyle J, Winston M, Sideris J, Martin G, Nayar K, Bush L J Autism Dev Disord. 2022; 53(5):1989-2005.

PMID: 35194728 PMC: 9932999. DOI: 10.1007/s10803-022-05459-5.

Social communication in fragile X syndrome: pilot examination of the Brief Observation of Social Communication Change (BOSCC).

Shaffer R, Thurman A, Ronco L, Cadavid D, Raines S, Kim S J Neurodev Disord. 2022; 14(1):4.

PMID: 35034602 PMC: 8903546. DOI: 10.1186/s11689-021-09411-z.

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