Interaction of Stress, Corticotropin-releasing Factor, Arginine Vasopressin and Behaviour

Overview

Journal Curr Top Behav Neurosci

Publisher Springer

Specialty Psychology

Date 2014 Mar 25

PMID 24659554

Citations 20

Authors

Eleonore Beurel

Charles B Nemeroff

Affiliations

Soon will be listed here.

Abstract

Stress mediates the activation of a variety of systems ranging from inflammatory to behavioral responses. In this review we focus on two neuropeptide systems, corticotropin-releasing factor (CRF) and arginine vasopressin (AVP), and their roles in regulating stress responses. Both peptides have been demonstrated to be involved in anxiogenic and depressive effects, actions mediated in part through their regulation of the hypothalamic-pituitary-adrenal axis and the release of adrenocorticotropic hormone. Because of the depressive effects of CRF and AVP, drugs modifying the stress-associated detrimental actions of CRF and AVP are under development, particularly drugs antagonizing CRF and AVP receptors for therapy in depression.

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