Hemoglobin Causes Both Endothelium-dependent and Endothelium-independent Contraction of the Pig Coronary Arteries, Independently of an Inhibition of EDRF Effects

Overview

Journal Experientia

Specialty Science

Date 1989 Feb 15

PMID 2465913

Citations 2

Authors

J L Beny

P C BRUNET

V van Der Bent

Affiliations

Soon will be listed here.

Abstract

Hemoglobin is widely used as an inhibitor of EDRF effects. Hemoglobin contracts pig coronary arteries in vitro. However, during this contraction, effects of substance P and bradykinin which act via the EDRF are not inhibited. This means that the hemoglobin contraction is not caused by inhibition of the EDRF. This contraction is caused by a substance released from the endothelium, and by eicosanoïds released from the smooth muscles.

Citing Articles

Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

Simon B, Cunningham L, Cohen R J Clin Invest. 1990; 86(1):75-9.

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Effect of nitro-L-arginine on endothelium-dependent hyperpolarizations and relaxations of pig coronary arteries.

Pacicca C, von der Weid P, Beny J J Physiol. 1992; 457:247-56.

PMID: 1284311 PMC: 1175729. DOI: 10.1113/jphysiol.1992.sp019376.

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