Is Disorganization a Feature of Schizophrenia or a Modifying Influence: Evidence of Covariation of Perceptual and Cognitive Organization in a Non-patient Sample

Overview

Journal Psychiatry Res

Specialty Psychiatry

Date 2014 Mar 25

PMID 24656898

Citations 11

Authors

Keith A Feigenson

Michael A Gara

Matthew W Roche

Steven M Silverstein

Affiliations

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Abstract

A subgroup of people with schizophrenia is characterized by reduced organization in perception, thought, language, and motor functioning, and these impairments covary significantly. While this may reflect multiple expressions of an illness-related core processing impairment, it may also represent the extreme end of an organization-disorganization dimension that is found throughout the general population. In this view, disorganization is a modifying influence on illness expression. To obtain preliminary information on this hypothesis, we examined covariation of perceptual and cognitive organization in a non-patient sample. Subjects completed a battery of perceptual tasks with demonstrated sensitivity to schizophrenia and disorganization, and a battery of questionnaires examining cognitive organization. Our results indicated that level of perceptual organization ability, across multiple tasks, was associated with self-reported levels of cognitive organization on multiple measures. This is thus preliminary evidence for a common process affecting perceptual and cognitive organization in the general population, suggesting that disorganization may reflect a modifying influence mechanism, instead of an illness-related process, in schizophrenia.

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References

Butler P, Abeles I, Silverstein S, Dias E, Weiskopf N, Calderone D . An event-related potential examination of contour integration deficits in schizophrenia. Front Psychol. 2013; 4:132. PMC: 3604636. DOI: 10.3389/fpsyg.2013.00132. View

Chmielewski P, Fernandes L, Yee C, Miller G . Ethnicity and gender in scales of psychosis proneness and mood disorders. J Abnorm Psychol. 1995; 104(3):464-70. DOI: 10.1037//0021-843x.104.3.464. View

Chen Y . Abnormal visual motion processing in schizophrenia: a review of research progress. Schizophr Bull. 2011; 37(4):709-15. PMC: 3122297. DOI: 10.1093/schbul/sbr020. View

Peralta V, Cuesta M . The relationship between syndromes of the psychotic illness and familial liability to schizophrenia and major mood disorders. Schizophr Res. 2007; 91(1-3):200-9. DOI: 10.1016/j.schres.2006.12.018. View

Kwapil T, Barrantes-Vidal N, Silvia P . The dimensional structure of the Wisconsin Schizotypy Scales: factor identification and construct validity. Schizophr Bull. 2007; 34(3):444-57. PMC: 2632435. DOI: 10.1093/schbul/sbm098. View

Silverstein S, Knight R, Schwarzkopf S, West L, Osborn L, Kamin D . Stimulus configuration and context effects in perceptual organization in schizophrenia. J Abnorm Psychol. 1996; 105(3):410-20. DOI: 10.1037//0021-843x.105.3.410. View

Doherty M, Campbell N, Tsuji H, Phillips W . The Ebbinghaus illusion deceives adults but not young children. Dev Sci. 2010; 13(5):714-21. DOI: 10.1111/j.1467-7687.2009.00931.x. View

Uhlhaas P, Haenschel C, Nikolic D, Singer W . The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr Bull. 2008; 34(5):927-43. PMC: 2632472. DOI: 10.1093/schbul/sbn062. View

Lindenmayer J, Grochowski S . A new five factor model of schizophrenia. Psychiatr Q. 1994; 65(4):299-322. DOI: 10.1007/BF02354306. View

10.

Sham P, Castle D, Wessely S, Farmer A, Murray R . Further exploration of a latent class typology of schizophrenia. Schizophr Res. 1996; 20(1-2):105-15. DOI: 10.1016/0920-9964(95)00091-7. View

11.

Kay J, Phillips W . Coherent Infomax as a computational goal for neural systems. Bull Math Biol. 2010; 73(2):344-72. DOI: 10.1007/s11538-010-9564-x. View

12.

Claridge G . The schizophrenias as nervous types. Br J Psychiatry. 1972; 121(560):1-17. DOI: 10.1192/bjp.121.1.1. View

13.

Kwapil T, Miller M, Zinser M, Chapman L, Chapman J, Eckblad M . A longitudinal study of high scorers on the hypomanic personality scale. J Abnorm Psychol. 2000; 109(2):222-6. View

14.

Nikolaev A, Gepshtein S, Gong P, van Leeuwen C . Duration of coherence intervals in electrical brain activity in perceptual organization. Cereb Cortex. 2009; 20(2):365-82. PMC: 2803735. DOI: 10.1093/cercor/bhp107. View

15.

Cox M, LEVENTHAL D . A multivariate analysis and modification of a preattentive, perceptual dysfunction in schizophrenia. J Nerv Ment Dis. 1978; 166(10):709-18. DOI: 10.1097/00005053-197810000-00004. View

16.

Wickham H, Walsh C, Asherson P, Taylor C, Sigmundson T, Gill M . Familiality of symptom dimensions in schizophrenia. Schizophr Res. 2001; 47(2-3):223-32. DOI: 10.1016/s0920-9964(00)00098-0. View

17.

Pizlo Z, Li Z . Solving combinatorial problems: the 15-puzzle. Mem Cognit. 2006; 33(6):1069-84. DOI: 10.3758/bf03193214. View

18.

Eysenck H . The continuity of abnormal and normal behavior. Psychol Bull. 1958; 55(6):429-32. DOI: 10.1037/h0048574. View

19.

Uhlhaas P, Phillips W, Mitchell G, Silverstein S . Perceptual grouping in disorganized schizophrenia. Psychiatry Res. 2006; 145(2-3):105-17. DOI: 10.1016/j.psychres.2005.10.016. View

20.

Insel T, Cuthbert B, Garvey M, Heinssen R, Pine D, Quinn K . Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010; 167(7):748-51. DOI: 10.1176/appi.ajp.2010.09091379. View