The Nano-plasma Interface: Implications of the Protein Corona

Overview

Journal Colloids Surf B Biointerfaces

Publisher Elsevier

Specialty Chemistry

Date 2014 Mar 25

PMID 24656615

Citations 53

Authors

Joy Wolfram

Yong Yang

Jianliang Shen

Asad Moten

Chunying Chen

Haifa Shen

Mauro Ferrari

Yuliang Zhao

Affiliations

Soon will be listed here.

Abstract

The interactions between nanoparticles and macromolecules in the blood plasma dictate the biocompatibility and efficacy of nanotherapeutics. Accordingly, the properties of nanoparticles and endogenous biomolecules change at the nano-plasma interface. Here, we review the implications of such changes including toxicity, immunological recognition, molecular targeting, biodistribution, intracellular uptake, and drug release. Although this interface poses several challenges for nanomedicine, it also presents opportunities for exploiting nanoparticle-protein interactions.

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